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AB101940

Recombinant Human HDHD2 protein

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Recombinant Human HDHD2 protein is a Human Full Length protein, in the 1 to 259 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Haloacid dehalogenase-like hydrolase domain-containing protein 2, HDHD2

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SDS-PAGE - Recombinant Human HDHD2 protein (AB101940)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human HDHD2 protein (AB101940)

15% SDS-PAGE analysis of 3μg ab101940.

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9H0R4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAACRALKAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDFKGIQTSDPNAVVMGLAPEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCESFPHAVDHILQHLL","proteinLength":"Full Length","predictedMolecularWeight":"30.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":259,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H0R4","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HDHD2 also known as haloacid dehalogenase-like hydrolase domain-containing protein 2 is an enzyme with a molecular weight of approximately 22 kDa. It primarily functions as a phosphatase which removes phosphate groups from specific substrates. HDHD2 is expressed in several tissues including the liver and brain. Its activity is integral to regulating phosphate metabolism and maintaining cellular homeostasis.
Biological function summary

HDHD2 hydrolyzes phosphoserines and plays an essential role in dephosphorylation processes. It is a component of protein complexes that control phosphorylation states within cells directly affecting protein functions. Through these actions HDHD2 influences cellular signaling and metabolism contributing to physiological processes such as enzyme regulation and substrate modification.

Pathways

HDHD2 participates in signaling pathways related to phosphate metabolism and energy balance. It is related to the energy production pathway and the regulation of cellular signaling cascades. This protein interacts with other enzymes like PPARG and PTPMT1 coordinating the maintenance of phosphate balance across cellular compartments.

Abnormalities in HDHD2 function can be linked to metabolic disorders including diabetes and obesity. Its disturbance affects phosphate homeostasis and potentially contributes to insulin resistance. HDHD2 interacts with proteins such as insulin receptors and SREBP-1c implicating it in metabolic dysregulation associated with these conditions.
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Specifications

Form

Liquid

Additional notes

ab101940 is purified using conventional chromatography techniques.

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General info

Sequence similarities

Belongs to the HAD-like hydrolase superfamily.

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Product protocols

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Target data

See full target information Haloacid dehalogenase-like hydrolase domain-containing protein 2
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Secondary Antibodies

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