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AB104901

Recombinant Human HDHD3 protein

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Recombinant Human HDHD3 protein is a Human Full Length protein, in the 1 to 251 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C9orf158, HDHD3, Haloacid dehalogenase-like hydrolase domain-containing protein 3

1 Images
SDS-PAGE - Recombinant Human HDHD3 protein (AB104901)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HDHD3 protein (AB104901)

15% SDS-PAGE analysis of 3ug ab104901

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

DDDDK tag N-Terminus His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9BSH5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMAHRLQIRLLTWDVKDTLLRLRHPLGEAYATKARAHGLEVEPSALEQGFRQAYRAQSHSFPNYGLSHGLTSRQWWLDVVLQTFHLAGVQDAQAVAPIAEQLYKDFSHPCTWQVLDGAEDTLRECRTRGLRLAVISNFDRRLEGILEGLGLREHFDFVLTSEAAGWPKPDPRIFQEALRLAHMEPVVAAHVGDNYLCDYQGPRAVGMHSFLVVGPQALDPVVRDSVPKEHILPSLAHLLPALDCLEGSTPGL","proteinLength":"Full Length","predictedMolecularWeight":"32.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":251,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BSH5","tags":[{"tag":"DDDDK","terminus":"N-Terminus"},{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein HDHD3 also known as haloacid dehalogenase-like hydrolase domain-containing 3 functions as a phosphatase enzyme. It belongs to the HAD superfamily and weighs approximately 26 kDa. Researchers find HDHD3 expressed in various tissues with notable presence in the liver and kidney. Its expression pattern and activity suggest a specialized role in intracellular processes that involve phosphate metabolism.
Biological function summary

The enzyme HDHD3 catalyzes the hydrolysis of phosphoester bonds therefore playing a role in removing phosphate groups from phosphorylated molecules. It does not commonly associate with larger protein complexes operating as a standalone enzyme. Its hydrolase activity suggests involvement in regulating cellular phosphate levels impacting metabolic and signaling processes within cells.

Pathways

HDHD3 participates in pathways that regulate intracellular phosphorus homeostasis. It influences the phosphorus cycle by interacting with molecules involved in phosphate metabolism and regulating their phosphate group statuses. This enzymatic activity might work alongside other phosphatases like PTEN which also participates in dephosphorylation activities within cellular pathways to modulate phosphate group distribution and balance.

Researchers have observed potential connections between HDHD3 dysregulation and metabolic disorders particularly related to phosphate metabolism. Alterations in the activity or expression of HDHD3 might affect phosphate homeostasis leading to conditions such as hypophosphatemia or hyperphosphatemia. Its role in these disorders may intersect with other phosphatases like ALPL which is involved in bone mineralization possibly linking it to skeletal anomalies when either is altered in their function.
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Specifications

Form

Liquid

Additional notes

ab104901 is purified using conventional chromatography.

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General info

Sequence similarities

Belongs to the HAD-like hydrolase superfamily.

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Product protocols

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Target data

See full target information HDHD3
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