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AB183220

Recombinant Human Heat Shock Factor 2 Binding Protein

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Recombinant Human Heat Shock Factor 2 Binding Protein is a Human Full Length protein, in the 1 to 334 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

MEILB2, HSF2BP, Heat shock factor 2-binding protein

1 Images
SDS-PAGE - Recombinant Human Heat Shock Factor 2 Binding Protein (AB183220)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Heat Shock Factor 2 Binding Protein (AB183220)

15% SDS-PAGE analysis of ab183220 (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

O75031

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGEAGAAEEACRHMGTKEEFVKVRKKDLERLTTEVMQIRDFLPRILNGEVLESFQKLKIVEKNLERKEQELEQLKMDCEHFKARLETVQADNIREKKEKLALRQQLNEAKQQLLQQAEYCTEMGAAACTLLWGVSSSEEVVKAILGGDKALKFFSITGQTMESFVKSLDGDVQELDSDESQFVFALAGIVTNVAAIACGREFLVNSSRVLLDTILQLLGDLKPGQCTKLKVLMLMSLYNVSINLKGLKYISESPGFIPLLWWLLSDPDAEVCLHVLRLVQSVVLEPEVFSKSASEFRSSLPLQRILAMSKSRNPRLQTAAQELLEDLRTLEHNV","proteinLength":"Full Length","predictedMolecularWeight":"40 kDa","actualMolecularWeight":null,"aminoAcidEnd":334,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75031","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Heat Shock Factor 2 Binding Protein (HSF2BP) takes part in the regulation of heat shock response by interacting with Heat Shock Factor 2 (HSF2). It has a molecular mass of approximately 39 kDa. Expression of HSF2BP occurs mainly in testes though smaller amounts might be found in other tissues. HSF2BP directly associates with HSF2 altering its activity under stress conditions and regulates the transcription of heat shock proteins that protect cells from stress-induced damage.
Biological function summary

HSF2BP modulates stress response mechanisms by influencing the availability of HSF2. It forms a complex with other proteins and regulates protein stability. This protein exerts control over the expression of genes involved in stress response and cellular protection. HSF2BP's activity equates to a regulatory checkpoint in the cellular stress response ensuring appropriate chaperone activity and protein folding.

Pathways

HSF2BP intersects with the molecular chaperone network and the protein quality control pathways in cells. It interacts with pathways involving HSF2 and Heat Shock Factor 1 (HSF1) both critical for maintaining cellular integrity under stress conditions. HSF2BP influences these pathways by regulating the dynamic assembly of the transcription complex impacting gene expression profiles during stress response events.

HSF2BP relates to reproductive and developmental health including infertility and neurodegenerative diseases. Aberrant expression or mutations in HSF2BP can disrupt the balance of cellular stress responses potentially contributing to disease states. Its interaction with HSF2 and HSF1 implicates it in disorders such as Alzheimer's where protein misfolding and stress response mechanisms are compromised. Understanding HSF2BP's role in these diseases could help to identify targets for therapeutic intervention.
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Specifications

Form

Liquid

Additional notes

ab183220 was purified using conventional chromatography techniques.

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General info

Function

Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1 : RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed : 31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed : 9651507).

Post-translational modifications

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.

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Product protocols

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Target data

Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1 : RAD51 to meiotic double-strand break (DSB) sites through the interaction with BRCA2 and its recruitment during meiotic recombination (By similarity) (PubMed : 31242413). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (By similarity). Required for proper recombinase recruitment in female meiosis (By similarity). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). May be involved in modulating HSF2 activation in testis (PubMed : 9651507).
See full target information HSF2BP
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