Recombinant Human heavy chain Myosin/MYH3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Heavy chain Myosin also known as MYH3 is a protein involved in muscle contraction. Alternative names for this protein include Myosin heavy chain and MyHC with a molecular mass of approximately 223 kDa. This protein is primarily expressed in skeletal muscle tissues during fetal development. The heavy chain myosin is a part of the larger family of myosin proteins which are motor proteins found in most eukaryotic cells.

Biological function summary

Heavy chain Myosin functions to convert chemical energy from ATP into mechanical energy facilitating muscle contraction. It serves as the backbone for thick filaments playing a significant role in muscle fiber composition. Myosin heavy chain forms a complex with actin filaments and this actin-myosin interaction is essential for muscle contraction and force generation. This protein can associate with different myosin light chains and regulatory proteins which modulate its activity.

Pathways

Heavy chain Myosin is an important player in the muscle contraction pathway. This pathway is critical for muscle development and maintenance influencing how muscles respond to stimuli. Actin and tropomyosin are vital collaborators in this process with the interaction between actin and MyHC being central to contraction. The troponin complex acts as a regulatory unit within the pathway controlling the exposure of active sites on actin filaments.

Mutations in the MYH3 gene can cause conditions like Freeman-Sheldon syndrome and distal arthrogryposis type 2A. These disorders are characterized by joint contractures and muscle abnormalities. MYH3 mutations alter the normal function of the myosin protein affecting muscle development. Additionally heavy chain Myosin interacts with other muscle-related proteins such as actin and myosin-binding protein C linking it to various skeletal muscle disorders.