Recombinant Human HEPACAM protein is a Human Fragment protein, in the 34 to 240 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
V N I T S P V R L I H G T V G K S A L L S V Q Y S S T S S D R P V V K W Q L K R D K P V T V V Q S I G T E V I G T L R P D Y R D R I R L F E N G S L L L S D L Q L A D E G T Y E V E I S I T D D T F T G E K T I N L T V D V P I S R P Q V L V A S T T V L E L S E A F T L N C S H E N G T K P S Y T W L K D G K P L L N D S R M L L S P D Q K V L T I T R V L M E D D D L Y S C M V E N P I S Q G R S L P V K I T V Y R R S S V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205).
Hepatic and glial cell adhesion molecule, glialCAM, Hepatocyte cell adhesion molecule, Protein hepaCAM, HEPACAM
Recombinant Human HEPACAM protein is a Human Fragment protein, in the 34 to 240 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 7.2
Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride
Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205).
N-glycosylated.
HEPACAM also known as "glialCAM" is a transmembrane glycoprotein that weighs approximately 55-65 kDa. It primarily appears in the glial cells of the central nervous system and plays a significant role in cell adhesion and communication. Researchers identified this protein in astrocytes oligodendrocytes and ependymal cells. It interacts with other cell adhesion molecules to mediate interactions between glial cells and contributes to maintaining the structural integrity of tissues.
HEPACAM functions in the context of cell-cell adhesion and signal transduction mechanisms. This protein does not operate in isolation but rather forms part of larger protein complexes enhancing its role in cellular scaffolding and molecular signaling networks. The interaction with other cellular machinery supports processes like cell migration proliferation and differentiation which are critical for maintaining the homeostasis of neural tissues. Studies also highlight its role in modulating immune response and inflammatory processes within the nervous system.
HEPACAM integrates into specific pathways involving cellular adhesion and signal transduction such as the PI3K/AKT signaling pathway. This pathway plays an important role in controlling cell growth and survival. HEPACAM's interaction with molecules like integrins and other cell adhesion proteins strengthens its function within this pathway. For instance integrins contribute to the regulation of the extracellular matrix composition affecting cellular movements and interactions vital for immune surveillance and responses in the nervous system.
Research associates HEPACAM with conditions like epilepsy and leukodystrophy. Alterations in HEPACAM expression or function can lead to improper cell adhesion disrupting normal tissue architecture and contributing to pathological states. Additionally there are links between HEPACAM and connexins proteins involved in forming gap junctions which further emphasizes its role in conditions characterized by impaired cellular communication. These associations highlight HEPACAM's involvement in maintaining neural stability and function within the central nervous system.
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