Recombinant Human HERC3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HERC3 protein also known as HECT and RLD domain containing E3 ubiquitin protein ligase 3 functions as an E3 ubiquitin ligase involved in protein ubiquitination. It weighs approximately 120 kDa and is part of the ubiquitin-proteasome system which regulates protein degradation by tagging proteins for disposal. HERC3 is widely expressed in various tissues making it an important regulatory component in many cellular functions.

Biological function summary

Researchers identify HERC3 as an important player in regulating intracellular processes such as cell cycle progression and signal transduction. It participates in protein quality control by marking defective or surplus proteins for degradation. Although not a part of larger multi-protein complexes itself HERC3 interacts closely with other ubiquitin-conjugating enzymes and substrates ensuring that ubiquitination is targeted accurately to specific proteins.

Pathways

HERC3 has integral roles in the ubiquitin-proteasome pathway and also influences the phosphatidylinositol 3-kinase (PI3K) signaling pathway. Through the ubiquitin-proteasome pathway it interacts with and regulates various target proteins like p53 a well-known tumor suppressor. In the PI3K pathway HERC3's regulatory actions can impact processes like cell growth and survival linking it to cellular responses to external stimuli.

Researchers associate abnormalities in HERC3 with cancer and neurodegenerative diseases. In cancer its regulation of p53 ubiquitination can affect tumor suppression activities potentially leading to tumor formation or progression. Neurodegenerative disorders like Alzheimer's disease involve protein aggregation and HERC3's role in protein quality control may influence the pathology. Additionally its interaction with E3 ubiquitin ligases like Parkin might connect it to Parkinson’s disease pathways.