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AB168071

Recombinant Human HES2 protein (denatured)

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(1 Publication)

Recombinant Human HES2 protein (denatured) is a Human Full Length protein, in the 1 to 173 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

BHLHB40, HES2, Transcription factor HES-2, Class B basic helix-loop-helix protein 40, Hairy and enhancer of split 2, bHLHb40

1 Images
SDS-PAGE - Recombinant Human HES2 protein (denatured) (AB168071)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HES2 protein (denatured) (AB168071)

3 μg ab168071 on 15% SDS-PAGE

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9Y543

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMGLPRRAGDAAELRKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPASSWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSGPSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW","proteinLength":"Full Length","predictedMolecularWeight":"20.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":173,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y543","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HES2 short for Hairy and Enhancer of Split 2 is a basic helix-loop-helix (bHLH) transcriptional repressor. It belongs to the Hes family of genes known for their role in transcriptional regulation. HES2 weighs around 27 kiloDaltons. You can find HES2 expressed mainly in developing tissues such as embryonic stem cells and neural tissues where it plays an important role in cell fate decisions.
Biological function summary

HES2 functions as a transcriptional regulator by binding to specific DNA sequences. It plays an important role in maintaining the balance between proliferation and differentiation. HES2 acts as part of the Notch signaling pathway complex. This pathway is important in numerous developmental processes including the regulation of neurogenesis and myogenesis.

Pathways

HES2 actively participates in the Notch signaling pathway and interacts with other pathway components like HEY1 and DLL1. These interactions help regulate gene expression patterns necessary for stem cell maintenance and differentiation. It also contributes to the MAPK/ERK pathway facilitating various cellular processes such as cell survival and proliferation particularly through its interactions with E proteins.

HES2 has been linked to neurodegenerative disorders and certain cancers. Altered expression or mutations in HES2 can lead to developmental abnormalities contributing to conditions like glioblastoma. The target's dysregulation can affect Notch signaling thereby affecting proteins such as JAG1 and NOTCH1 which have known associations with these disorders.
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Specifications

Form

Liquid

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General info

Function

Transcriptional repressor of genes that require a bHLH protein for their transcription.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcriptional repressor of genes that require a bHLH protein for their transcription.
See full target information HES2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oxidative medicine and cellular longevity 2022:7676872 PubMed36238644

2022

Lead Exposure Induced Neural Stem Cells Death via Notch Signaling Pathway and Gut-Brain Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Lijuan Sun,Yuankang Zou,Peng Su,Chong Xue,Diya Wang,Fang Zhao,Wenjing Luo,Jianbin Zhang
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