Recombinant Human HEXIM1 protein (Tagged)
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Recombinant Human HEXIM1 protein (Tagged) is a Human Full Length protein, in the 1 to 359 aa range, expressed in Wheat germ, suitable for SDS-PAGE.
View Alternative Names
CLP1, EDG1, HIS1, MAQ1, HEXIM1, Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human HEXIM1 protein (Tagged) (AB275910)
12.5% SDS-PAGE stained with Coomassie Blue.
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HEXIM1 serves a critical regulatory role within the transcription machinery in cells. It acts as an essential component of the HEXIM1/P-TEFb/7SK snRNP complex which helps maintain transcriptional homeostasis. This complex involves 7SK small nuclear RNA which makes the transcription process more efficient by sequestering P-TEFb in an inactive state. By doing this HEXIM1 controls the release and activation of P-TEFb ensuring accurate transcription regulation and preventing aberrant gene expression.
Pathways
HEXIM1 is an integral element in managing transcription elongation processes. It is known to be part of significant signaling pathways such as the P-TEFb dependent transcription pathway. HEXIM1 interacts with proteins like CDK9 and cyclin T1 that are fundamental to its regulatory function. By controlling these interactions HEXIM1 influences RNA polymerase II's transition into productive elongation mode essential for proper gene expression.
Specifications
Form
Liquid
General info
Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed : 14580347, PubMed : 15201869, PubMed : 15713661). Core component of the 7SK RNP complex : in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed : 12832472, PubMed : 14580347, PubMed : 15201869, PubMed : 15713661). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed : 15940264, PubMed : 15941832, PubMed : 17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed : 28712728).
Sequence similarities
Belongs to the HEXIM family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
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