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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Recombinant human HGF protein (Active) is a Human Full Length protein, in the 32 to 728 aa range, expressed in BTI-TN-5B1-4, with >=98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
>=98% SDS-PAGE
< 1 EU/µg
BTI-TN-5B1-4 cells
Tag free
SDS-PAGE, FuncS, HPLC
Yes
Q R K R R N T I H E F K K S A K T T L I K I D P A L K I K T K K V N T A D Q C A N R C T R N K G L P F T C K A F V F D K A R K Q C L W F P F N S M S S G V K K E F G H E F D L Y E N K D Y I R N C I I G K G R S Y K G T V S I T K S G I K C Q P W S S M I P H E H S F L P S S Y R G K D L Q E N Y C R N P R G E E G G P W C F T S N P E V R Y E V C D I P Q C S E V E C M T C N G E S Y R G L M D H T E S G K I C Q R W D H Q T P H R H K F L P E R Y P D K G F D D N Y C R N P D G Q P R P W C Y T L D P H T R W E Y C A I K T C A D N T M N D T D V P L E T T E C I Q G Q G E G Y R G T V N T I W N G I P C Q R W D S Q Y P H E H D M T P E N F K C K D L R E N Y C R N P D G S E S P W C F T T D P N I R V G Y C S Q I P N C D M S H G Q D C Y R G N G K N Y M G N L S Q T R S G L T C S M W D K N M E D L H R H I F W E P D A S K L N E N Y C R N P D D D A H G P W C Y T G N P L I P W D Y C P I S R C E G D T T P T I V N L D H P V I S C A K T K Q L R V V N G I P T R T N I G W M V S L R Y R N K H I C G G S L I K E S W V L T A R Q C F P S R D L K D Y E A W L G I H D V H G R G D E K C K Q V L N V S Q L V Y G P E G S D L V L M K L A R P A V L D D F V S T I D L P N Y G C T I P E K T S C S V Y G W G Y T G L I N Y D G L L R V A H L Y I M G N E K C S Q H H R G K V T L N E S E I C A G A E K I G S G P C E G D Y G G P L V C E Q H K M R M V L G V I V P G R G C A I P N R P G I F V R V A Y Y A K W I H K I I L T Y K V P Q S
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, HPTA, HGF
Recombinant human HGF protein (Active) is a Human Full Length protein, in the 32 to 728 aa range, expressed in BTI-TN-5B1-4, with >=98% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS, HPLC.
Hepatocyte growth factor, Hepatopoietin-A, Scatter factor, SF, HPTA, HGF
>=98% SDS-PAGE
< 1 EU/µg
BTI-TN-5B1-4 cells
Tag free
SDS-PAGE, FuncS, HPLC
Yes
Determined by the dose-dependent stimulation of the proliferation of monkey 4MBr-5 cells. The expected ED50 for this effect is 1.0-20.0 ng/ml.
No
Yes
Human
Reconstitute at 0.5 mg/mL in water
Constituents: 1.74% DL-Arginine, 1.16% Sodium chloride, 0.12% Tris
Q R K R R N T I H E F K K S A K T T L I K I D P A L K I K T K K V N T A D Q C A N R C T R N K G L P F T C K A F V F D K A R K Q C L W F P F N S M S S G V K K E F G H E F D L Y E N K D Y I R N C I I G K G R S Y K G T V S I T K S G I K C Q P W S S M I P H E H S F L P S S Y R G K D L Q E N Y C R N P R G E E G G P W C F T S N P E V R Y E V C D I P Q C S E V E C M T C N G E S Y R G L M D H T E S G K I C Q R W D H Q T P H R H K F L P E R Y P D K G F D D N Y C R N P D G Q P R P W C Y T L D P H T R W E Y C A I K T C A D N T M N D T D V P L E T T E C I Q G Q G E G Y R G T V N T I W N G I P C Q R W D S Q Y P H E H D M T P E N F K C K D L R E N Y C R N P D G S E S P W C F T T D P N I R V G Y C S Q I P N C D M S H G Q D C Y R G N G K N Y M G N L S Q T R S G L T C S M W D K N M E D L H R H I F W E P D A S K L N E N Y C R N P D D D A H G P W C Y T G N P L I P W D Y C P I S R C E G D T T P T I V N L D H P V I S C A K T K Q L R V V N G I P T R T N I G W M V S L R Y R N K H I C G G S L I K E S W V L T A R Q C F P S R D L K D Y E A W L G I H D V H G R G D E K C K Q V L N V S Q L V Y G P E G S D L V L M K L A R P A V L D D F V S T I D L P N Y G C T I P E K T S C S V Y G W G Y T G L I N Y D G L L R V A H L Y I M G N E K C S Q H H R G K V T L N E S E I C A G A E K I G S G P C E G D Y G G P L V C E Q H K M R M V L G V I V P G R G C A I P N R P G I F V R V A Y Y A K W I H K I I L T Y K V P Q S
Full Length
80 kDa
32 to 728
Recombinant
Lyophilized
>=98% HPLC analyses.Sterile filtered.
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Belongs to the peptidase S1 family. Plasminogen subfamily.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Expression System = Baculovirus infected High-5 cells.
HGF plays an essential role in cellular growth regeneration and healing processes across different tissues. It is not part of a complex but functions as a single-chain polypeptide that undergoes cleavage into its active form. HGF facilitates cell proliferation and migration; this is especially important during organ regeneration and repair processes. By engaging with its receptor c-Met it induces cell survival and cytoskeletal reorganization making it important for wound healing.
The hepatocyte growth factor (HGF) also known as scatter factor (SF) is a protein with a mass of approximately 83 kDa. This protein is mostly expressed in the liver but it can also be found in other organs such as the kidney and the lungs. HGF acts mechanically by binding to the c-Met receptor activating intracellular signaling mechanisms necessary for various physiological processes. Researchers often use HGF ELISA kits to measure its levels in biological samples and study its various roles.
HGF is critical in the MAPK and PI3K-Akt signaling pathways which impact processes like cell division and survival. Through these pathways HGF interacts with other proteins such as ERK and Akt contributing to the regulation of cellular growth and metabolism. HGF's role in these pathways highlights its importance in developmental processes and tissue homeostasis.
HGF displays significant connections to cancer and liver cirrhosis. Its overexpression can lead to the development of various carcinomas due to its effect on cell proliferation and migration. In liver cirrhosis the altered HGF-c-Met signaling might contribute to the disease progression and hepatic dysfunction. Additionally HGF can interact with proteins such as transforming growth factor-beta (TGF-β) in these conditions influencing the pathological environment.
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Full details and terms and conditions can be found here:
Terms & Conditions.
Standard curve for HGF (Analyte: ab632); dilution range 1pg/ml to 1μg/ml using Capture Antibody ab10829 at 5μg/ml and Detector Antibody ab24865 at 0.5μg/ml.
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