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AB132409

Recombinant Human HIRIP3 protein (GST tag N-Terminus)

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Recombinant Human HIRIP3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 556 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

HIRA-interacting protein 3, HIRIP3

1 Images
SDS-PAGE - Recombinant Human HIRIP3 protein (GST tag N-Terminus) (AB132409)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HIRIP3 protein (GST tag N-Terminus) (AB132409)

12.5% SDS-PAGE analysis of ab132409, stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q9BW71

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAREKEMQEFTRSFFRGRPDLSTLTHSIVRRRYLAHSGRSHLEPEEKQALKRLVEEELLKMQVDEAASREDKLDLTKKGKRPPTPCSDPERKRFRFNSESESGSEASSPDYFGPPAKNGVAAEVSPAKEENPRRASKAVEESSDEERQRDLPAQRGEESSEEEEKGYKGKTRKKPVVKKQAPGKASVSRKQAREESEESEAEPVQRTAKKVEGNKGTKSLKESEQESEEEILAQKKEQREEEVEEEEKEEDEEKGDWKPRTRSNGRRKSAREERSCKQKSQAKRLLGDSDSEEEQKEAASSGDDSGRDREPPVQRKSEDRTQLKGGKRLSGSSEDEEDSGKGEPTAKGSRKMARLGSTSGEESDLEREVSDSEAGGGPQGERKNRSSKKSSRKGRTRSSSSSSDGSPEAKGGKAGSGRRGEDHPAVMRLKRYIRACGAHRNYKKLLGSCCSHKERLSILRAELEALGMKGTPSLGKCRALKEQREEAAEVASLDVANIISGSGRPRRRTAWNPLGEAAPPGELYRRTLDSDEERPRPAPPDWSHMRGIISSDGESN","proteinLength":"Full Length","predictedMolecularWeight":"88.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":556,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BW71","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HIRIP3 also known as HIRA-interacting protein 3 is a protein with a mass of approximately 60 kDa. This protein is expressed in various tissues with notable presence in testis and brain. HIRIP3 mechanistically interacts with HIRA a chaperone involved in histone metabolism. The protein contains motifs that suggest a role in chromatin organization and regulation and it may be involved in transcription processes through these interactions.
Biological function summary

HIRIP3 participates in the regulation of chromatin dynamics and gene expression. It forms a complex with HIRA and other proteins linked to chromatin assembly influencing nucleosome spacing and stability. This interaction helps regulate the incorporation of histone H3.3 a variant important for active chromatin remodeling and transcriptional activation suggesting a direct role in controlling genetic activity in cells.

Pathways

Researchers have identified HIRIP3 as integral to the chromatin assembly pathway and histone modification processes. It associates with the HIRA complex impacting histone replacement during DNA repair and transcription. HIRIP3’s relationship with proteins like ASF1a indicates its involvement in chromatin remodeling processes important for maintaining genome stability and regulation of gene expression.

Disruptions in the HIRIP3 expression or function could relate to neurodegenerative diseases or infertility given its expression profile. Abnormalities in the HIRA interaction have been considered in the context of these conditions. The association of HIRIP3 with proteins involved in histone modification suggests that its dysregulation may contribute to epigenetic disorders which can lead to improper gene silencing or activation linked to pathological states.
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Specifications

Form

Liquid

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General info

Function

Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin.

Post-translational modifications

Phosphorylated by CK2.

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Product protocols

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Target data

Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin.
See full target information HIRIP3
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