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AB159926

Recombinant Human Histone acetyltransferase MYST3/MOZ protein (GST tag N-Terminus)

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Recombinant Human Histone acetyltransferase MYST3/MOZ protein (GST tag N-Terminus) is a Human Fragment protein, in the 81 to 179 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

MOZ, MYST3, RUNXBP2, ZNF220, KAT6A, Histone acetyltransferase KAT6A, Monocytic leukemia zinc finger protein, Runt-related transcription factor-binding protein 2, Zinc finger protein 220, MYST-3

1 Images
SDS-PAGE - Recombinant Human Histone acetyltransferase MYST3/MOZ protein (GST tag N-Terminus) (AB159926)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Histone acetyltransferase MYST3/MOZ protein (GST tag N-Terminus) (AB159926)

ab159926 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q92794

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Histone acetyltransferase MYST3.
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Sequence info

[{"sequence":"ALPKPRNHGKLDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGK","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":179,"aminoAcidStart":81,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q92794","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Histone acetyltransferase MYST3 also known as MOZ (Monocytic Leukemia Zinc Finger Protein) is an enzyme with acetyltransferase activity. It primarily acetylates histones influencing chromatin structure and gene expression. MYST3/MOZ has a molecular weight of approximately 270 kDa. Researchers observe its expression mainly in the nucleus where it plays important roles in transcriptional regulation. Apart from its activity on histones MYST3 also acts on non-histone proteins contributing to various cellular processes.
Biological function summary

This protein functions in regulating gene expression by modifying chromatin structure. It is a part of the large MYST family named for its founding members (MOZ YBF2/Sas3 Sas2 Tip60) which together form various multiprotein complexes. These complexes participate in critical biological processes like cell proliferation and differentiation. MYST3/MOZ acts as a transcriptional coactivator promoting acetylation that results in an open chromatin conformation conducive to transcription initiation.

Pathways

Acetyltransferases like MYST3/MOZ integrate into wider cellular signaling networks. Notably it plays a role in the transcription regulation pathway and the hematopoiesis pathway. These roles connect MYST3/MOZ to proteins such as RUNX1 a critical transcription factor in hematopoiesis. It's through these pathways that MYST3/MOZ influences cellular functioning and development demonstrating its importance in maintaining normal cellular activities.

Mutations or translocations involving MYST3/MOZ often associate with hematological malignancies notably acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The protein's interactions with RUNX1 in these disorders highlight its role in disrupting normal hematopoiesis. Understanding MYST3/MOZ's function and its role in disease progression can guide therapeutic development targeted at chromatin remodeling mechanisms in associated cancers.
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Specifications

Form

Liquid

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General info

Function

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (PubMed : 11742995, PubMed : 11965546). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed : 11965546). May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed : 12771199). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (PubMed : 23431171). May play a role in leukemogenic gene transcription (PubMed : 39794553).

Sequence similarities

Belongs to the MYST (SAS/MOZ) family.

Post-translational modifications

Autoacetylated; autoacetylation at Lys-604 is required for proper function (Ref.27). Acetylation at Lys-1007 and Lys-1014 is required for the interaction with MLLT1/ENL and MLLT3/AF9 (PubMed:39794553).. Crotonylated; crotonylation at Lys-1007 and Lys-1014 promotes the interaction with MLLT1/ENL and MLLT3/AF9.. Phosphorylation at Thr-369 by PKB/AKT1 inhibits its interaction with PML and negatively regulates its acetylation activity towards p53/TP53.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro) (PubMed : 11742995, PubMed : 11965546). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed : 11965546). May act as a transcriptional coactivator for RUNX1 and RUNX2 (PubMed : 12771199). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (PubMed : 23431171). May play a role in leukemogenic gene transcription (PubMed : 39794553).
See full target information KAT6A
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