Recombinant Human Histone H2A + Histone H2B + Histone H4 + Histone H3 protein (Tag Free)
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Recombinant Human Histone H2A + Histone H2B + Histone H4 + Histone H3 protein (Tag Free) is a Human Full Length protein, expressed in HeLa cells, with >90%, suitable for SDS-PAGE.
View Alternative Names
H2BFS, H2BS1, H2BC12L, Histone H2B type F-S, H2B-clustered histone 12 like, H2B.S histone 1, Histone H2B.s, H2B/s, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FC HIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J, HIST1H3C, H3FC, H3C1, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l, H2AFM, HIST1H2AB, H2AC8, H2AFA, HIST1H2AE, H2AC4, Histone H2A type 1-B/E, Histone H2A.2, Histone H2A/a, Histone H2A/m, H2BFF, HIST1H2BB, H2BC3, Histone H2B type 1-B, H2B-clustered histone 3, Histone H2B.1, Histone H2B.f, H2B/f, H2BFL, HIST1H2BC, H2BC6, H2BFH, HIST1H2BE, H2BC7, H2BFG, HIST1H2BF, H2BC8, H2BFA, HIST1H2BG, H2BC10, H2BFK, HIST1H2BI, H2BC4, Histone H2B type 1-C/E/F/G/I, Histone H2B.1 A, Histone H2B.a, Histone H2B.g, Histone H2B.h, Histone H2B.k, Histone H2B.l, H2B/a, H2B/g, H2B/h, H2B/k, H2B/l, H2BFC, HIST1H2BL, H2BC13, Histone H2B type 1-L, Histone H2B.c, H2B/c, H4/A, H4FA, HIST1H4A, H4C2, H4/I, H4FI, HIST1H4B, H4C3, H4/G, H4FG, HIST1H4C, H4C4, H4/B, H4FB, HIST1H4D, H4C5, H4/J, H4FJ, HIST1H4E, H4C6, H4/C, H4FC, HIST1H4F, H4C8, H4/H, H4FH, HIST1H4H, H4C9, H4/M, H4FM, HIST1H4I, H4C11, H4/E, H4FE, HIST1H4J, H4C12, H4/D, H4FD, HIST1H4K, H4C13, H4/K, H4FK, HIST1H4L, H4C14, H4/N, H4F2, H4FN, HIST2H4, HIST2H4A, H4C15, H4/O, H4FO, HIST2H4B, H4C16, H4-16, HIST4H4, H4C1, Histone H4, H2AW, HIST3H2A, H2AC25, Histone H2A type 3, H2A-clustered histone 25, H2BFR, HIST1H2BJ, H2BC11, Histone H2B type 1-J, Histone H2B.1, Histone H2B.r, H2B/r, H2BFD, HIST1H2BN, H2BC15, Histone H2B type 1-N, Histone H2B.d, H2B/d, H2BFE, HIST1H2BM, H2BC14, Histone H2B type 1-M, Histone H2B.e, H2B/e, HIST1H2AH, HIST1H2AI, H2AC12, Histone H2A type 1-H, H2A-clustered histone 12, Histone H2A/s, H2BFH, H2BFN, HIST1H2BO, H2BC17, Histone H2B type 1-O, H2B-clustered histone 17, Histone H2B.2, Histone H2B.n, H2B/n, H2BFB, HIRIP2, HIST1H2BD, H2BC5, Histone H2B type 1-D, H2B-clustered histone 5, HIRA-interacting protein 2, Histone H2B.1 B, Histone H2B.b, H2B/b, HIST2H2BF, H2BC18, Histone H2B type 2-F, H2B-clustered histone 18, H2AFE, HIST1H2AJ, H2AC14, Histone H2A type 1-J, Histone H2A/e, H2AFL, HIST1H2AC, H2AC6, Histone H2A type 1-C, H2A-clustered histone 6, Histone H2A/l, HIST2H2AB, H2AC21, Histone H2A type 2-B, H2A-clustered histone 21, H2AFR, HIST1H2AA, H2AC1, Histone H2A type 1-A, H2A-clustered histone 1, Histone H2A/r, H2AFO, HIST2H2AA, HIST2H2AA3, H2AC19, HIST2H2AA4, H2AC18, Histone H2A type 2-A, H2A-clustered histone 18, H2A-clustered histone 19, Histone H2A.2, Histone H2A/o, H2AFQ, HIST2H2AC, H2AC20, Histone H2A type 2-C, H2A-clustered histone 20, Histone H2A-GL101, Histone H2A/q, TTHERM_00316500, HTA2, Histone H2A.1, Histone H2A.2, H2A2, H2AFG, HIST1H2AD, H2AC7, Histone H2A type 1-D, Histone H2A.3, Histone H2A/g, H2BU1, HIST3H2BB, H2BC26, Histone H2B type 3-B, H2B type 12, H2B-clustered histone 26, H2B.U histone 1, H2BFJ, HIST1H2BH, H2BC9, Histone H2B type 1-H, H2B-clustered histone 9, Histone H2B.j, H2B/j, H2BFT, HIRIP1, HIST1H2BK, H2BC12, Histone H2B type 1-K, H2B K, HIRA-interacting protein 1, H2BFQ, HIST2H2BE, H2BC21, Histone H2B type 2-E, H2B-clustered histone 21, Histone H2B-GL105, Histone H2B.q, H2B/q
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human Histone H2A + Histone H2B + Histone H4 + Histone H3 protein (Tag Free) (AB271796)
SDS-PAGE analysis of ab271796.
Complementary Products
Primary Antibodies
AB1791
Anti-Histone H3 antibody - Nuclear Marker and ChIP Grade
Lab Essentials
- 5
- 233
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Specifications
Form
Liquid
General info
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Sequence similarities
Belongs to the histone H2B family.
Post-translational modifications
Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.. Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation (PubMed:12757711). Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.. GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).. ADP-ribosylated by PARP1 or PARP2 on Ser-7 (H2BS6ADPr) in response to DNA damage (PubMed:34874266). H2BS6ADPr promotes recruitment of CHD1L (PubMed:34874266). Mono-ADP-ribosylated on Glu-3 (H2BE2ADPr) by PARP3 in response to single-strand breaks (PubMed:27530147). Poly ADP-ribosylation on Glu-36 (H2BE35ADPr) by PARP1 regulates adipogenesis: it inhibits phosphorylation at Ser-37 (H2BS36ph), thereby blocking expression of pro-adipogenetic genes (By similarity).. Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.. Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription.
Subcellular localisation
Nucleus
Target data
Additional targets
Product promise
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