Recombinant Human HMGA1a / HMGA1b protein
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Recombinant Human HMGA1a / HMGA1b protein is a Human Full Length protein, in the 1 to 107 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
HMGIY, HMGA1, High mobility group protein HMG-I/HMG-Y, HMG-I(Y), High mobility group AT-hook protein 1, High mobility group protein R, High mobility group protein A1
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human HMGA1a / HMGA1b protein (AB109927)
15% SDS-PAGE showing ab109927 at approximately 12.7 kDa (3µg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
Additional notes
ab109927 is purified using conventional chromatography techniques.
General info
Function
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Sequence similarities
Belongs to the HMGA family.
Post-translational modifications
Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.. HMG-Y is not methylated.. Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
Subcellular localisation
Nucleus
Product protocols
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Target data
Product promise
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