Recombinant Human HMGCS1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

This enzyme contributes to the synthesis of cholesterol and other isoprenoids. HMGCS1 is not typically part of a multi-protein complex but operates downstream of acetyl-CoA in the mevalonate pathway. Its activity helps maintain cellular homeostasis by regulating the pool of HMG-CoA an important precursor in cholesterol and ketone bodies synthesis. The modulation of HMGCS1 activity impacts cellular proliferation and growth given the pathway's connection to sterol and non-sterol isoprenoid production.

Pathways

The enzyme participates chiefly in the mevalonate and cholesterol biosynthesis pathways. It functions alongside HMG-CoA reductase (HMGCR) which converts HMG-CoA to mevalonate further linking to cholesterol synthesis and regulatory pathways. The interrelation of HMGCS1 with other enzymes like HMGCR highlights its significance in lipid metabolism and cellular energy balance influencing pathways essential for cell membrane synthesis and signaling molecules production.