Recombinant Human HMGN3 protein (His tag N-Terminus)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human HMGN3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 77 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
View Alternative Names
TRIP7, PNAS-24, HMGN3, High mobility group nucleosome-binding domain-containing protein 3, Thyroid receptor-interacting protein 7, TR-interacting protein 7, TRIP-7
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human HMGN3 protein (His tag N-Terminus) (AB183234)
15% SDS-PAGE analysis of ab183234 (3μg)
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HMGN3 functions by modulating the access of transcription factors to DNA. It is not a part of any known multi-protein complex but acts independently. By altering the chromatin landscape HMGN3 plays a role in the regulation of genes involved in metabolism and neurodevelopment impacting cellular processes like energy balance and synaptic function.
Pathways
HMGN3 participates in the insulin signaling and neurodevelopmental pathways. It influences the insulin signaling pathway by affecting genes that manage glucose metabolism. Related proteins include insulin receptor substrate 1 (IRS1) as they work together to ensure proper metabolic responses. In the neurodevelopmental context HMGN3 interacts with pathways involving the brain-derived neurotrophic factor (BDNF) contributing to the development and plasticity of neurons.
Specifications
Form
Liquid
Additional notes
ab183234 was purified using conventional chromatography.
General info
Function
Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
Sequence similarities
Belongs to the HMGN family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com