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AB116438

Recombinant Human HN1 protein

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Recombinant Human HN1 protein is a Human Full Length protein, in the 1 to 181 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.

View Alternative Names

ARM2, HN1, JPT1, Jupiter microtubule associated homolog 1, Androgen-regulated protein 2, Hematological and neurological expressed 1 protein

1 Images
Western blot - Recombinant Human HN1 protein (AB116438)
  • WB

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Western blot - Recombinant Human HN1 protein (AB116438)

10% SDS-PAGE stained with Coomassie Blue (Lane 1), immunobloting with anti-6xHis (Lane 2)

All lanes:

Western blot - Recombinant Human HN1 protein (ab116438)

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Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, ELISA, SDS-PAGE, WB

applications

Biologically active

No

Accession

Q9UK76

Animal free

No

Carrier free

Yes

Species

Human

Storage buffer

pH: 7.4 Constituents: 99% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"23.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":181,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"Q9UK76","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HN1 also known as Hematological and Neurological Expressed 1 protein is a small protein with a mass of approximately 10 kDa. It expresses in various tissues mainly in hematopoietic and neurological cells. Researchers also identified its expression in some cancerous tissues which suggests its potential role in tumor biology. HN1 exhibits a notable presence in cytoplasmic and nuclear compartments indicating its involvement in multiple cellular processes.
Biological function summary

Experts believe HN1 participates in cellular development and differentiation. It does not function alone but interacts with other proteins within a larger complex affecting intracellular signaling. This interaction hints at the protein's role in supporting the regulation of cellular growth and hematopoiesis. In addition HN1 influences cellular responses to stress which further supports its relevance in development and disease.

Pathways

HN1 integrates into the Jak-STAT signaling pathway and possibly the Notch signaling pathway. This association with significant signaling pathways implies its role in modulating gene expression linked to cell proliferation and differentiation. HN1 also shows interactions with other proteins in these pathways such as STAT3 suggesting collaborative involvement in regulating cellular responses to external stimuli.

Scientists have linked HN1 to cancer and neurodegenerative diseases. Its upregulation in various cancer types like breast cancer indicates a potential role in tumor cell proliferation and survival. Additionally in neurodegenerative conditions changes in HN1 expression suggest it might contribute to neuronal dysfunction. Connections to related proteins like BCL2 involved in cell survival highlight HN1’s implications in both cancer progression and neurodegenerative pathways.
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Specifications

Form

Liquid

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General info

Function

Modulates negatively AKT-mediated GSK3B signaling (PubMed : 21323578, PubMed : 22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC : CTNNB1 : GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed : 25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed : 25169422, PubMed : 25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed : 22155408).

Sequence similarities

Belongs to the JUPITER family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Modulates negatively AKT-mediated GSK3B signaling (PubMed : 21323578, PubMed : 22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC : CTNNB1 : GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed : 25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed : 25169422, PubMed : 25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed : 22155408).
See full target information JPT1
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