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AB139791

Recombinant Human HN1L/L11 protein (His tag N-Terminus)

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Recombinant Human HN1L/L11 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 190 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

C16orf34, HN1L, L11, JPT2, Jupiter microtubule associated homolog 2, Hematological and neurological expressed 1-like protein, HN1-like protein

1 Images
SDS-PAGE - Recombinant Human HN1L/L11 protein (His tag N-Terminus) (AB139791)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HN1L/L11 protein (His tag N-Terminus) (AB139791)

SDS-PAGE analysis of ab139791 (3μg) under reducing conditions with coomassie blue protein stain

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9H910

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as HN1L
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMFQVPDSEGGRAGSRAMKPPGGESSNLFGSPEEATPSSRPNRMASNIFGPTEEPQNIPKRTNPPGGKGSGIFDESTPVQTRQHLNPPGGKTSDIFGSPVTATSRLAHPNKPKDHVFLCEGEEPKSDLKAARSIPAGAEPGEKGSARKAGPAKEQEPMPTVDSHEPRLGPRPRSHNKVLNPPGGKSSISFY","proteinLength":"Full Length","predictedMolecularWeight":"22.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":190,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9H910","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HN1L/L11 protein also known as Hematological and Neurological Expressed 1-Like has a molecular weight of approximately 19 kDa. It is expressed in various tissues including the liver and brain. Mechanically HN1L/L11 is involved in the regulation of cellular growth and proliferation although the exact mechanisms remain under investigation. Researchers often focus on its potential role in modulating gene expression and supporting cellular stress responses.
Biological function summary

HN1L/L11 plays a part in critical cellular functions that support homeostasis. This protein operates within cellular complexes that regulate transcription processes and it may interact with molecular machinery involved in stress adaptation. HN1L/L11's involvement in these essential cellular activities indicates its potential broader impact on maintaining cell survival and integrity in fluctuating environments.

Pathways

HN1L/L11 plays a role in signaling pathways linked to stress response and apoptosis regulation. Notably it is associated with the MAPK and the JAK/STAT pathways which are pivotal in cell survival and differentiation. Through these pathways HN1L/L11 shows interaction with other proteins such as JAK2 and STAT5 all contributing to the orchestration of cellular defense mechanisms under stress conditions.

Researchers have linked HN1L/L11 to various cancer types and neurodegenerative disorders. In cancer the protein's regulation of cell growth pathways implicates its potential role in tumor development and progression often in connection with proteins like p53. In neurodegenerative conditions aberrant expression or function of HN1L/L11 may contribute to neuronal stress and degeneration suggesting it could serve as a biomarker or therapeutic target in such diseases.
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Specifications

Form

Liquid

Additional notes

ab139791 is purified using conventional chromatography techniques.

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General info

Function

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed : 33758061, PubMed : 33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed : 33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed : 33758062).. (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.

Sequence similarities

Belongs to the JUPITER family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Nicotinic acid adenine dinucleotide phosphate (NAADP) binding protein required for NAADP-evoked intracellular calcium release (PubMed : 33758061, PubMed : 33758062). Confers NAADP-sensitivity to the two pore channels (TPCs) complex (PubMed : 33758061). Enables NAADP to activate Ca(2+) release from the endoplasmic reticulum through ryanodine receptors (PubMed : 33758062).. (Microbial infection) Involved in the endolysosomal trafficking of human coronavirus SARS-CoV-2.
See full target information JPT2
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