Recombinant Human HNRPAB protein is a Human protein, in the 1 to 285 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S E A G E E Q P M E T T G A T E N G H E A V P E G E S P A G A G T G A A A G A G G A T A A P P S G N Q N G A E G D Q I N A S K N E E D A G K M F V G G L S W D T S K K D L K D Y F T K F G E V V D C T I K M D P N T G R S R G F G F I L F K D A A S V E K V L D Q K E H R L D G R V I D P K K A M A M K K D P V K K I F V G G L N P E A T E E K I R E Y F G E F G E I E A I E L P M D P K L N K R R G F V F I T F K E E E P V K K V L E K K F H T V S G S K C E I K V A Q P K E V Y Q Q Q Q Y G S G G R G N R N R G N R G S G G G G G G G G Q G S T N Y G K S Q R R G G H Q N N Y K P Y
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
Alternative names
ABBP1, HNRPAB, HNRNPAB, Heterogeneous nuclear ribonucleoprotein A/B, hnRNP A/B, APOBEC1-binding protein 1, ABBP-1
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Recombinant Human HNRPAB protein is a Human protein, in the 1 to 285 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q99729-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S E A G E E Q P M E T T G A T E N G H E A V P E G E S P A G A G T G A A A G A G G A T A A P P S G N Q N G A E G D Q I N A S K N E E D A G K M F V G G L S W D T S K K D L K D Y F T K F G E V V D C T I K M D P N T G R S R G F G F I L F K D A A S V E K V L D Q K E H R L D G R V I D P K K A M A M K K D P V K K I F V G G L N P E A T E E K I R E Y F G E F G E I E A I E L P M D P K L N K R R G F V F I T F K E E E P V K K V L E K K F H T V S G S K C E I K V A Q P K E V Y Q Q Q Q Y G S G G R G N R N R G N R G S G G G G G G G G Q G S T N Y G K S Q R R G G H Q N N Y K P Y
- Accession
- Q99729
- Predicted molecular weight
- 33 kDa
- Amino acids
- 1 to 285
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab171508 is purified using conventional chromatography techniques.
General info
- Function
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
- Post-translational modifications
Dimethylation at Arg-322 is probably asymmetric.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Heterogeneous nuclear ribonucleoprotein A/B often called HNRPAB functions as a part of the ribonucleoprotein complex. This protein interacts with pre-mRNA in the nucleus and influences its processing. HNRPAB has a molecular mass of about 37 kilodaltons. Scientists find it highly expressed in various tissues including the brain and testis indicating its significant role in these areas. The protein contains RNA-binding domains and plays a part in the regulation of alternative splicing.
- Biological function summary
HNRPAB influences the splicing and transport of pre-mRNA impacting the maturation process of mRNA. It collaborates with other hnRNPs and splicing factors to modulate gene expression. The protein sometimes forms part of larger complexes that are essential for RNA processing. This complex helps to stabilize RNA molecules assisting in their proper transport and translation in the cytoplasm.
- Pathways
HNRPAB is involved in the regulation of RNA metabolism and processing pathways. It forms a network with other proteins like hnRNP F and hnRNP H impacting gene expression by influencing mRNA stability and availability. In conjunction with these proteins HNRPAB plays a role in the signal transduction pathways affecting cellular responses and adaptations.
- Associated diseases and disorders
HNRPAB has connections to cancer and neurodegenerative disorders. Its dysregulation can lead to abnormal splicing patterns contributing to oncogenesis. In cancer associations with proteins like c-Myc indicate a role in tumorigenesis. In neurodegenerative diseases altered HNRPAB activity could impact neuronal survival contributing to the progression of disorders like Alzheimer’s disease. The protein’s interaction with tau suggests a potential link to tauopathies which are related to abnormal protein aggregations within neurons.
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SDS-PAGE - Recombinant Human HNRPAB protein (ab171508)
15% SDS-PAGE analysis of ab171508 (3μg).
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