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AB171508

Recombinant Human HNRPAB protein (His tag N-Terminus)

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Recombinant Human HNRPAB protein (His tag N-Terminus) is a Human protein, in the 1 to 285 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

ABBP1, HNRPAB, HNRNPAB, Heterogeneous nuclear ribonucleoprotein A/B, hnRNP A/B, APOBEC1-binding protein 1, ABBP-1

1 Images
SDS-PAGE - Recombinant Human HNRPAB protein (His tag N-Terminus) (AB171508)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HNRPAB protein (His tag N-Terminus) (AB171508)

15% SDS-PAGE analysis of ab171508 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q99729

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSEAGEEQPMETTGATENGHEAVPEGESPAGAGTGAAAGAGGATAAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGGLNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQGSTNYGKSQRRGGHQNNYKPY","proteinLength":null,"predictedMolecularWeight":"33 kDa","actualMolecularWeight":null,"aminoAcidEnd":285,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q99729","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Heterogeneous nuclear ribonucleoprotein A/B often called HNRPAB functions as a part of the ribonucleoprotein complex. This protein interacts with pre-mRNA in the nucleus and influences its processing. HNRPAB has a molecular mass of about 37 kilodaltons. Scientists find it highly expressed in various tissues including the brain and testis indicating its significant role in these areas. The protein contains RNA-binding domains and plays a part in the regulation of alternative splicing.
Biological function summary

HNRPAB influences the splicing and transport of pre-mRNA impacting the maturation process of mRNA. It collaborates with other hnRNPs and splicing factors to modulate gene expression. The protein sometimes forms part of larger complexes that are essential for RNA processing. This complex helps to stabilize RNA molecules assisting in their proper transport and translation in the cytoplasm.

Pathways

HNRPAB is involved in the regulation of RNA metabolism and processing pathways. It forms a network with other proteins like hnRNP F and hnRNP H impacting gene expression by influencing mRNA stability and availability. In conjunction with these proteins HNRPAB plays a role in the signal transduction pathways affecting cellular responses and adaptations.

HNRPAB has connections to cancer and neurodegenerative disorders. Its dysregulation can lead to abnormal splicing patterns contributing to oncogenesis. In cancer associations with proteins like c-Myc indicate a role in tumorigenesis. In neurodegenerative diseases altered HNRPAB activity could impact neuronal survival contributing to the progression of disorders like Alzheimer’s disease. The protein’s interaction with tau suggests a potential link to tauopathies which are related to abnormal protein aggregations within neurons.
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Specifications

Form

Liquid

Additional notes

ab171508 is purified using conventional chromatography techniques.

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General info

Function

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Post-translational modifications

Dimethylation at Arg-322 is probably asymmetric.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.
See full target information HNRNPAB
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Complementary Products

Primary Antibodies

AB199724

Anti-HNRPAB antibody [EPR16944]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-HNRPAB antibody [EPR16944] (AB199724)

  • 4
  • 1
Primary Antibodies

AB289974

Anti-hnRNP H antibody [EPR25302-12]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-hnRNP H antibody [EPR25302-12] (AB289974)

  • 0
  • 0
Cell Lines & Lysates

AB266459

Human HNRNPAB knockout HEK-293T cell line

Advanced Validation

Western blot - Human HNRNPAB knockout HEK-293T cell line (AB266459)

  • 0
  • 0
Primary Antibodies

AB151251

Anti-hnRNP R antibody

KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-hnRNP R antibody (AB151251)

  • 0
  • 0

Product promise

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