Recombinant Human HNRPH2/HNRNPH2 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HNRPH2 also known as hnRNP H2 is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. It assists in RNA binding and processing playing a role in pre-mRNA splicing and mRNA metabolism. HNRPH2 has a molecular mass of approximately 49 kDa. Researchers have identified its expression in various tissues with a notable presence in the nucleus where RNA processing occurs.

Biological function summary

HNRPH2 participates in critical cellular mechanisms involving RNA. It plays a role in hnRNP complexes which help in the nuclear-cytoplasmic transport of mRNAs. This protein aids in alternative splicing which allows cells to produce multiple protein variants from a single gene. By binding to specific sequences on RNA HNRPH2 influences the maturation and stability of RNA molecules ensuring accurate gene expression.

Pathways

HNRPH2 functions in the regulation of gene expression and RNA splicing pathways. It associates with the spliceosome which is essential in removing introns from pre-mRNA. This activity links it to processes like the alternative splicing pathway integral for creating protein diversity in cells. Interactions with other hnRNP proteins such as hnRNP A1 highlight its involvement in maintaining cellular RNA homeostasis.

Alterations in HNRPH2 are linked to neurological disorders and cancers. Mutations in the HNRPH2 gene have been associated with Bainbridge-Ropers syndrome a neurodevelopmental disorder suggesting the gene's role in neural development. Disruptions in its function may also relate to cancer where the abnormal splicing of mRNAs can promote tumorigenesis. HNRPH2's interaction with proteins such as TDP-43 implies its possible involvement in neurodegenerative diseases.