Recombinant Human HOMER2 protein is a Human Fragment protein, in the 32 to 317 aa range, expressed in Escherichia coli, with >50% purity and suitable for SDS-PAGE.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Homer protein homolog 2, Homer-2, Cupidin, HOMER2
Recombinant Human HOMER2 protein is a Human Fragment protein, in the 32 to 317 aa range, expressed in Escherichia coli, with >50% purity and suitable for SDS-PAGE.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Purified via His tag
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).
Belongs to the Homer family.
HOMER2 also known as Homeobox protein homolog 2 is a scaffold protein with a mass of approximately 40 kDa. It is expressed in several tissues most notably in the brain and skeletal muscle. This protein interacts with various cellular components due to its structural domains which allow for versatile connections with other proteins. HOMER2 localizes primarily in the postsynaptic density of neuronal synapses where it plays a critical role in synaptic signaling.
HOMER2 contributes to the organization and regulation of synaptic transmission. It forms part of a higher-order signaling complex interacting with metabotropic glutamate receptors and IP3 receptors. This role helps modulate intracellular calcium release which is significant for many neurophysiological processes. HOMER2 also influences cellular responses by binding to ryanodine receptors highlighting its involvement in important neurobiological processes.
The function of HOMER2 integrates into key signaling pathways in the brain such as the mGluR (metabotropic glutamate receptor) pathway. Through these pathways HOMER2 interacts with proteins like SHANK and GRM which are integral components in maintaining synaptic plasticity and communication. It also contributes to the regulation of the calcium signaling pathway by associating with IP3R which influences calcium release from intracellular stores.
HOMER2 has implications in conditions such as schizophrenia and addiction. Research suggests that dysfunctions in HOMER2-related signaling may lead to altered neuronal communication potentially contributing to schizophrenia's pathophysiology. Additionally changes in HOMER2 expression or function might influence addictive behaviors as the protein is closely connected to the glutamatergic system that underpins many addiction mechanisms. Furthermore studies have indicated intersections with proteins like GRM5 and DLG4 in these contexts emphasizing HOMER2's importance in neuropathological states.
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