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AB126682

Recombinant Human HOMER3 protein (His tag N-Terminus)

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Recombinant Human HOMER3 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 361 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Homer protein homolog 3, Homer-3, HOMER3

1 Images
SDS-PAGE - Recombinant Human HOMER3 protein (His tag N-Terminus) (AB126682)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HOMER3 protein (His tag N-Terminus) (AB126682)

15% SDS-PAGE showing ab126682 (3 μg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9NSC5

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 30% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMMSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAAP","proteinLength":"Full Length","predictedMolecularWeight":"42.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":361,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NSC5","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The HOMER3 protein also known as Homer protein homolog 3 or Vesl-3 functions mechanically as a scaffolding protein. This protein belongs to the Homer/Vesl family and weighs around 37 kDa. The HOMER3 protein is expressed mainly in the brain specifically in the cerebellum cortex and hippocampus. By interacting with other proteins it modulates synaptic signaling and contributes to synaptic structure and plasticity.
Biological function summary

Within the family of Homer proteins HOMER3 acts by linking surface receptors to intracellular calcium release channels. It is an essential component of the postsynaptic density where it forms multimeric complexes. These complexes serve as a bridge between ion channels and metabotropic glutamate receptors (mGluRs) therefore playing a significant role in synaptic transmission and plasticity. By facilitating this interaction HOMER3 influences processes like learning and memory.

Pathways

HOMER3 is involved in two important biological pathways: the calcium signaling pathway and the mGluR signaling pathway. In the calcium signaling pathway HOMER3 interacts with proteins such as inositol 145-trisphosphate receptors (IP3Rs) to regulate calcium release from intracellular stores. In the mGluR signaling pathway it associates with mGluRs which influence synaptic transmissions in neurons and manage many neurological processes. The interactions and pathways are vital for proper neuronal function and plasticity.

HOMER3 has been connected to neurological diseases specifically schizophrenia and autism spectrum disorders. In schizophrenia altered HOMER3 expression can interact with proteins like dysbindin which impacts synaptic functions and neurotransmitter systems. In autism spectrum disorders changes in HOMER3-related pathways may affect mGluR signaling which is implicated in the synaptic deficits observed in these conditions. Understanding these connections can aid in developing targeted therapies for these neurological disorders.
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Specifications

Form

Liquid

Additional notes

ab126682 is purified using conventional chromatography techniques.

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General info

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed : 18218901).

Sequence similarities

Belongs to the Homer family.

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Product protocols

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Target data

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed : 18218901).
See full target information Homer protein homolog 3
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Complementary Products

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Secondary Antibodies

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