Recombinant Human HOXA11 protein is a Human Full Length protein, in the 1 to 313 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M D F D E R G P C S S N M Y L P S C T Y Y V S G P D F S S L P S F L P Q T P S S R P M T Y S Y S S N L P Q V Q P V R E V T F R E Y A I E P A T K W H P R G N L A H C Y S A E E L V H R D C L Q A P S A A G V P G D V L A K S S A N V Y H H P T P A V S S N F Y S T V G R N G V L P Q A F D Q F F E T A Y G T P E N L A S S D Y P G D K S A E K G P P A A T A T S A A A A A A A T G A P A T S S S D S G G G G G C R E T A A A A E E K E R R R R P E S S S S P E S S S G H T E D K A G G S S G Q R T R K K R C P Y T K Y Q I R E L E R E F F F S V Y I N K E K R L Q L S R M L N L T D R Q V K I W F Q N R R M K E K K I N R D R L Q Y Y S A N P L L
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Alternative names
HOX1I, HOXA11, Homeobox protein Hox-A11, Homeobox protein Hox-1I
Recommended products
Recombinant Human HOXA11 protein is a Human Full Length protein, in the 1 to 313 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- P31270-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M D F D E R G P C S S N M Y L P S C T Y Y V S G P D F S S L P S F L P Q T P S S R P M T Y S Y S S N L P Q V Q P V R E V T F R E Y A I E P A T K W H P R G N L A H C Y S A E E L V H R D C L Q A P S A A G V P G D V L A K S S A N V Y H H P T P A V S S N F Y S T V G R N G V L P Q A F D Q F F E T A Y G T P E N L A S S D Y P G D K S A E K G P P A A T A T S A A A A A A A T G A P A T S S S D S G G G G G C R E T A A A A E E K E R R R R P E S S S S P E S S S G H T E D K A G G S S G Q R T R K K R C P Y T K Y Q I R E L E R E F F F S V Y I N K E K R L Q L S R M L N L T D R Q V K I W F Q N R R M K E K K I N R D R L Q Y Y S A N P L L
- Accession
- P31270
- Protein length
- Full Length
- Amino acids
- 1 to 313
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
- Sequence similarities
Belongs to the Abd-B homeobox family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HOXA11 also known as homeobox A11 is a transcription factor involved in the regulation of gene expression. It belongs to the homeobox family and consists of about 33 kilodaltons. This target is expressed in various tissues including the uterus kidney and some parts of the nervous system. HOXA11 plays a significant role in the developmental process and cellular differentiation by binding to DNA sequences and influencing the transcriptional output of specific genes.
- Biological function summary
HOXA11 is essential in limb and organ development such as kidneys and the female reproductive tract. As part of the regulatory gene family it interacts with other transcription factors and proteins forming complexes that are pivotal for developmental processes. HOXA11 contributes to the patterning of embryonic territories by specifying the identity and spatial arrangement of segments along the body axes. This transcription factor's activity highlights its importance in normal physiological development.
- Pathways
HOXA11 functions are integral to the Wnt signaling pathway and the retinoic acid pathway. In these pathways HOXA11 can interact with proteins like Wnt which influences cellular processes such as proliferation differentiation and migration. The transcriptional regulation associated with HOXA11 is important for proper signaling within these pathways thereby impacting various developmental stages and processes.
- Associated diseases and disorders
HOXA11 has implications in congenital malformations and reproductive disorders. Mutations in HOXA11 may result in the malformation of limbs or conditions such as Mayer-Rokitansky-Küster-Hauser syndrome owing to its role in reproductive tract development. Additionally interactions with proteins like Wnt are also relevant since these interactions might contribute to the pathogenesis of developmental disorders highlighting the clinical significance of understanding HOXA11 function and regulation.
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1 product image
SDS-PAGE - Recombinant Human HOXA11 protein (ab158672)
ab158672 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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