Recombinant Human HOXA9 protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
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- Nature communications 9:14802018HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiang Zhou et. al.PubMed 29662084
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M A T T G A L G N Y Y V D S F L L G A D A A D E L S V G R Y A P G T L G Q P P R Q A A T L A E H P D F S P C S F Q S K A T V F G A S W N P V H A A G A N A V P A A V Y H H H H H H P Y V H P Q A P V A A A A P D G R Y M R S W L E P T P G A L S F A G L P S S R P Y G I K P E P L S A R R G D C P T L D T H T L S L T D Y A C G S P P V D R E K Q P S E G A F S E N N A E N E S G G D K P P I D P N N P A A N W L H A R S T R K K R C P Y T K H Q T L E L E K E F L F N M Y L T R D R R Y E V A R L L N L T E R Q V K I W F Q N R R M K M K K I N K D R A K D E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).
Alternative names
HOX1G, HOXA9, Homeobox protein Hox-A9, Homeobox protein Hox-1G
Recommended products
Recombinant Human HOXA9 protein is a Human Full Length protein, in the 1 to 272 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- P31269-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A T T G A L G N Y Y V D S F L L G A D A A D E L S V G R Y A P G T L G Q P P R Q A A T L A E H P D F S P C S F Q S K A T V F G A S W N P V H A A G A N A V P A A V Y H H H H H H P Y V H P Q A P V A A A A P D G R Y M R S W L E P T P G A L S F A G L P S S R P Y G I K P E P L S A R R G D C P T L D T H T L S L T D Y A C G S P P V D R E K Q P S E G A F S E N N A E N E S G G D K P P I D P N N P A A N W L H A R S T R K K R C P Y T K H Q T L E L E K E F L F N M Y L T R D R R Y E V A R L L N L T E R Q V K I W F Q N R R M K M K K I N K D R A K D E
- Accession
- P31269
- Protein length
- Full Length
- Predicted molecular weight
- 55.66 kDa
- Amino acids
- 1 to 272
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed:22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).
- Sequence similarities
Belongs to the Abd-B homeobox family.
- Post-translational modifications
Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HOXA9 also known as Homeobox A9 functions as a transcription factor and plays an important role in regulating gene expression during embryonic development and hematopoiesis. The protein has a mass of approximately 27 kDa. It shows expression in hematopoietic progenitor cells as well as in certain tissues like the lungs and the central nervous system. By binding to specific DNA sequences HOXA9 regulates genes that are vital for cellular differentiation and proliferation.
- Biological function summary
HOXA9 controls the transition and lineage commitment of hematopoietic stem cells. The protein often interacts as part of a transcriptional complex involving other HOX family proteins to maintain proper gene expression balance. This regulatory function is essential for normal gene expression patterns needed in stem cell differentiation and organ development processes.
- Pathways
HOXA9 plays significant roles in the hematopoietic cell lineage and the retinoic acid signaling pathway. Through these pathways it collaborates with other HOX proteins like HOXB4 to maintain stem cell properties and influence the differentiation process. These interactions facilitate the production of necessary blood cell types and ensure effective response mechanisms to various developmental cues.
- Associated diseases and disorders
HOXA9 shows a strong connection with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Overexpression or mutation of HOXA9 disturbs normal hematopoietic processes often leading to these malignancies. The interaction with protein PBX1 also highlights its role in these diseases as their joint involvement frequently appears in leukemogenesis. Understanding how HOXA9 contributes to these pathways is critical for developing targeted therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human HOXA9 protein (ab152453)
12.5% SDS-PAGE gel showing ab152453 stained with Coomassie Blue
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