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AB180306

Recombinant Human HOXA9 protein (denatured)

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Recombinant Human HOXA9 protein (denatured) is a Human Full Length protein, in the 1 to 272 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

HOX1G, HOXA9, Homeobox protein Hox-A9, Homeobox protein Hox-1G

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SDS-PAGE - Recombinant Human HOXA9 protein (denatured) (AB180306)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HOXA9 protein (denatured) (AB180306)

15% SDS-PAGE analysis of ab180306 (3 μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P31269

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMATTGALGNYYVDSFLLGADAADELSVGRYAPGTLGQPPRQAATLAEHPDFSPCSFQSKATVFGASWNPVHAAGANAVPAAVYHHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE","proteinLength":"Full Length","predictedMolecularWeight":"32.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":272,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P31269","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXA9 also known as Homeobox A9 functions as a transcription factor and plays an important role in regulating gene expression during embryonic development and hematopoiesis. The protein has a mass of approximately 27 kDa. It shows expression in hematopoietic progenitor cells as well as in certain tissues like the lungs and the central nervous system. By binding to specific DNA sequences HOXA9 regulates genes that are vital for cellular differentiation and proliferation.
Biological function summary

HOXA9 controls the transition and lineage commitment of hematopoietic stem cells. The protein often interacts as part of a transcriptional complex involving other HOX family proteins to maintain proper gene expression balance. This regulatory function is essential for normal gene expression patterns needed in stem cell differentiation and organ development processes.

Pathways

HOXA9 plays significant roles in the hematopoietic cell lineage and the retinoic acid signaling pathway. Through these pathways it collaborates with other HOX proteins like HOXB4 to maintain stem cell properties and influence the differentiation process. These interactions facilitate the production of necessary blood cell types and ensure effective response mechanisms to various developmental cues.

HOXA9 shows a strong connection with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Overexpression or mutation of HOXA9 disturbs normal hematopoietic processes often leading to these malignancies. The interaction with protein PBX1 also highlights its role in these diseases as their joint involvement frequently appears in leukemogenesis. Understanding how HOXA9 contributes to these pathways is critical for developing targeted therapeutic strategies.
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Specifications

Form

Liquid

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General info

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed : 22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).

Sequence similarities

Belongs to the Abd-B homeobox family.

Post-translational modifications

Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cells surface at sites of inflammation (PubMed : 22269951). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (By similarity).
See full target information HOXA9
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Secondary Antibodies

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