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AB158683

Recombinant Human HOXC9 protein (GST tag N-Terminus)

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Recombinant Human HOXC9 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 260 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

HOX3B, HOXC9, Homeobox protein Hox-C9, Homeobox protein Hox-3B

1 Images
SDS-PAGE - Recombinant Human HOXC9 protein (GST tag N-Terminus) (AB158683)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HOXC9 protein (GST tag N-Terminus) (AB158683)

ab158683 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

P31274

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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SDS-PAGE - Recombinant Human ZNF358 protein (GST tag N-Terminus) (AB165455)

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Recombinant Human ZBTB46 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZBTB46 protein (GST tag N-Terminus) (AB165467)

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Primary Antibodies

AB50839

Anti-HOXC9 antibody [HOXCA6E6]

Immunocytochemistry/ Immunofluorescence - Anti-HOXC9 antibody [HOXCA6E6] (AB50839)

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  • 5
Proteins & Peptides

AB165841

Recombinant Human UBR1 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UBR1 protein (GST tag N-Terminus) (AB165841)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSATGPISNYYVDSLISHDNEDLLASRFPATGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSVVYHPYGPQPHLGADTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPGRRADCGPGEGRSYPDYMYGSPGELRDRAPQTLPSPEADALAGSKHKEEKADLDPSNPVANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQNRRMKMKKMNKEKTDKEQS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":260,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P31274","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HOXC9 also known as Homeobox C9 is a transcription factor that belongs to the homeobox family specifically the HOX gene cluster. It regulates gene expression by binding to specific DNA sequences. The protein has a molecular mass of about 28 kDa. HOXC9 is expressed in various tissues including the nervous system particularly during embryonic development. It plays an important role in patterning the anterior-posterior axis and the development of specific body structures.
Biological function summary

Genes that HOXC9 regulates play key roles in developmental processes such as neural differentiation and limb formation. HOXC9 might operate as part of a larger transcriptional complex that involves other HOX proteins allowing precise control over developmental gene expression. The protein ensures that cells at different developmental stages respond correctly to morphogenetic signals facilitating proper organismal formation.

Pathways

HOXC9 actively participates in the retinoic acid signaling pathway important for neurodevelopmental regulation. This pathway requires a balance between HOXC9 and Receptor Interacting Protein 1 (RIP1) for correct gene expression. Another critical pathway is the Wnt signaling pathway where HOXC9 interacts with components such as beta-catenin to further modulate gene transcription related to cell fate decisions.

Research links HOXC9 dysregulation to neurodevelopmental disorders and certain cancers like leukemia. Abnormal HOXC9 expression disrupts regular neural development and contributes to malignancy. Its interaction with proteins including members of the Polycomb group like Bmi1 influences these pathologies. Understanding HOXC9's involvement helps in devising therapeutic strategies for these conditions.
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Specifications

Form

Liquid

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General info

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Sequence similarities

Belongs to the Abd-B homeobox family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
See full target information HOXC9
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Product promise

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