Recombinant Human HP-3 protein (Fc Chimera)

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

HP-3 also known as Hematopoietic Protein 3 acts as an important component in various cellular activities. It has a molecular mass of approximately 47 kDa. The protein is highly expressed in hematopoietic tissues particularly in the bone marrow and spleen. HP-3 is also present in smaller amounts in the liver and peripheral blood. Its expression in these areas indicates its essential role in blood cell formation and function.

Biological function summary

HP-3 plays an important role in the regulation of hematopoiesis the process which produces blood cells. The protein is not part of a larger complex but interacts closely with other proteins to regulate cell differentiation and proliferation. Its regulatory action supports both the maintenance of self-renewing stem cells and the differentiation of various blood lineages. This dual functionality emphasizes the protein's contribution to the body’s ability to sustain healthy and balanced blood cell populations.

Pathways

This protein is involved in the hematopoietic pathway. It also plays a role in the JAK/STAT signaling pathway influencing the differentiation and proliferation of hematopoietic stem cells. HP-3 interacts with proteins such as STAT5 and JAK2 which are central to facilitating signals that promote growth and division within blood cells. This relationship highlights HP-3's involvement in the essential signaling processes that maintain blood homeostasis.

Associated diseases and disorders

HP-3 shows significant connections to certain types of leukemia and anemia. Dysregulation or mutations of the HP-3 gene can lead to increased susceptibility or progression of acute myeloid leukemia. There is also an association with aplastic anemia a condition characterized by a failure of blood cell production. In these disorders HP-3 often interacts with proteins like FLT3 and EPO which also play roles in disease progression and therapeutic targeting. Understanding these connections can help guide better treatments and management strategies for affected patients.