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AB276637

Recombinant Human HP-3 protein (Fc Chimera)

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Recombinant Human HP-3 protein (Fc Chimera) is a Human Full Length protein, in the 39 to 94 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

DEF3, DEFA3, Neutrophil defensin 3, HNP-3, HP-3, HP3

1 Images
SDS-PAGE - Recombinant Human HP-3 protein (Fc Chimera) (AB276637)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human HP-3 protein (Fc Chimera) (AB276637)

SDS-PAGE analysis of ab276637

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P59666

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

Sequence info

[{"sequence":"DIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC","proteinLength":"Full Length","predictedMolecularWeight":"34.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":94,"aminoAcidStart":39,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P59666","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HP-3 also known as Hematopoietic Protein 3 acts as an important component in various cellular activities. It has a molecular mass of approximately 47 kDa. The protein is highly expressed in hematopoietic tissues particularly in the bone marrow and spleen. HP-3 is also present in smaller amounts in the liver and peripheral blood. Its expression in these areas indicates its essential role in blood cell formation and function.
Biological function summary

HP-3 plays an important role in the regulation of hematopoiesis the process which produces blood cells. The protein is not part of a larger complex but interacts closely with other proteins to regulate cell differentiation and proliferation. Its regulatory action supports both the maintenance of self-renewing stem cells and the differentiation of various blood lineages. This dual functionality emphasizes the protein's contribution to the body’s ability to sustain healthy and balanced blood cell populations.

Pathways

This protein is involved in the hematopoietic pathway. It also plays a role in the JAK/STAT signaling pathway influencing the differentiation and proliferation of hematopoietic stem cells. HP-3 interacts with proteins such as STAT5 and JAK2 which are central to facilitating signals that promote growth and division within blood cells. This relationship highlights HP-3's involvement in the essential signaling processes that maintain blood homeostasis.

HP-3 shows significant connections to certain types of leukemia and anemia. Dysregulation or mutations of the HP-3 gene can lead to increased susceptibility or progression of acute myeloid leukemia. There is also an association with aplastic anemia a condition characterized by a failure of blood cell production. In these disorders HP-3 often interacts with proteins like FLT3 and EPO which also play roles in disease progression and therapeutic targeting. Understanding these connections can help guide better treatments and management strategies for affected patients.

Specifications

Form

Lyophilized

General info

Function

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed : 15616305, PubMed : 15772169, PubMed : 17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed : 15772169, PubMed : 18435932, PubMed : 25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed : 17142766).

Sequence similarities

Belongs to the alpha-defensin family.

Product protocols

Target data

Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed : 15616305, PubMed : 15772169, PubMed : 17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed : 15772169, PubMed : 18435932, PubMed : 25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed : 17142766).
See full target information DEFA3

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