Recombinant Human HP-3 protein (Fc Chimera)
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Recombinant Human HP-3 protein (Fc Chimera) is a Human Full Length protein, in the 39 to 94 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
DEF3, DEFA3, Neutrophil defensin 3, HNP-3, HP-3, HP3
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human HP-3 protein (Fc Chimera) (AB276637)
SDS-PAGE analysis of ab276637
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
HP-3 plays an important role in the regulation of hematopoiesis the process which produces blood cells. The protein is not part of a larger complex but interacts closely with other proteins to regulate cell differentiation and proliferation. Its regulatory action supports both the maintenance of self-renewing stem cells and the differentiation of various blood lineages. This dual functionality emphasizes the protein's contribution to the body’s ability to sustain healthy and balanced blood cell populations.
Pathways
This protein is involved in the hematopoietic pathway. It also plays a role in the JAK/STAT signaling pathway influencing the differentiation and proliferation of hematopoietic stem cells. HP-3 interacts with proteins such as STAT5 and JAK2 which are central to facilitating signals that promote growth and division within blood cells. This relationship highlights HP-3's involvement in the essential signaling processes that maintain blood homeostasis.
Specifications
Form
Lyophilized
General info
Function
Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed : 15616305, PubMed : 15772169, PubMed : 17142766). Possesses the ability to neutralize bacterial toxins such as B. anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed : 15772169, PubMed : 18435932, PubMed : 25963798). Blocks also herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed : 17142766).
Sequence similarities
Belongs to the alpha-defensin family.
Target data
Product promise
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