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AB268608

Recombinant Human Hsp22/HSPB8 protein (Tagged)

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Recombinant Human Hsp22/HSPB8 protein (Tagged) is a Human Full Length protein, in the 1 to 196 aa range, expressed in Baculovirus infected Sf9 cells, with >95%, suitable for SDS-PAGE.

View Alternative Names

CRYAC, E2IG1, HSP22, PP1629, HSPB8, Heat shock protein beta-8, HspB8, Alpha-crystallin C chain, E2-induced gene 1 protein, Heat shock protein family B member 8, Protein kinase H11, Small stress protein-like protein HSP22

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SDS-PAGE - Recombinant Human Hsp22/HSPB8 protein (Tagged) (AB268608)
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Supplier Data

SDS-PAGE - Recombinant Human Hsp22/HSPB8 protein (Tagged) (AB268608)

SDS-PAGE analysis of ab268608.

MW ~50 kDa.

Key facts

Purity

>95% SDS-PAGE

Expression system

Baculovirus infected Sf9 cells

Tags

GST tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UJY1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MADGQMPFSCHYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTASWPDWALPRLSSAWPGTLRSGMVPRGPTATARFGVPAEGRTPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPPYSTFGESSFNNELPQDSQEVTCT","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":196,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Baculovirus infected Sf9 cells","accessionNumber":"Q9UJY1","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Hsp22 also known as HSPB8 is a small heat shock protein with a molecular weight of approximately 22 kDa. Expressed in various tissues including heart skeletal muscle and brain Hsp22 functions as a chaperone in cellular conditions. It prevents aggregation and aids in the refolding of misfolded proteins matching its role among the heat shock family proteins known for stress response.
Biological function summary

Hsp22 plays a critical role in maintaining protein homeostasis as part of a larger chaperone complex. It forms hetero-oligomers with other small heat shock proteins like HSPB1 and HSPB6 enhancing its protein-protective functions. These interactions allow Hsp22 to stabilize cytoskeletal elements and partake in autophagic pathways highlighting its importance during cellular stress conditions.

Pathways

Hsp22 integrates into cellular processes of autophagy and proteostasis. It participates in the chaperone-assisted selective autophagy (CASA) pathway. Here it associates with the cochaperone BAG3 facilitating the degradation of damaged proteins. Hsp22 also plays a role in the heat shock response pathway cooperating with other heat shock proteins like HSP70 to protect cells from damage induced by increased temperatures.

Hsp22 has associations with diseases like myopathy and neurodegeneration. In myopathies mutations in Hsp22 can disrupt normal muscular functions leading to muscle weakness and degeneration. In neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) abnormalities in the function or expression of Hsp22 together with its interaction with proteins such as HSPB1 can contribute to the disease's pathogenic mechanisms highlighting its clinical relevance.
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Specifications

Form

Liquid

Additional notes

Affinity purified.

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General info

Function

Displays temperature-dependent chaperone activity.

Sequence similarities

Belongs to the small heat shock protein (HSP20) family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Displays temperature-dependent chaperone activity.
See full target information HSPB8
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