Recombinant Human HSPB2 protein is a Human Full Length protein, in the 1 to 182 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S H M S G R S V P H A H P A T A E Y E F A N P S R L G E Q R F G E G L L P E E I L T P T L Y H G Y Y V R P R A A P A G E G S R A G A S E L R L S E G K F Q A F L D V S H F T P D E V T V R T V D N L L E V S A R H P Q R L D R H G F V S R E F C R T Y V L P A D V D P W R V R A A L S H D G I L N L E A P R G G R H L D T E V N E V Y I S L L P A P P D P E E E E E A A I V E P
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May regulate the kinase DMPK.
Alternative names
Heat shock protein beta-2, HspB2, DMPK-binding protein, Heat shock protein family B member 2, MKBP, HSPB2
Recommended products
Recombinant Human HSPB2 protein is a Human Full Length protein, in the 1 to 182 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >90% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q16082-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 20% Glycerol (glycerin, glycerine), 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S H M S G R S V P H A H P A T A E Y E F A N P S R L G E Q R F G E G L L P E E I L T P T L Y H G Y Y V R P R A A P A G E G S R A G A S E L R L S E G K F Q A F L D V S H F T P D E V T V R T V D N L L E V S A R H P Q R L D R H G F V S R E F C R T Y V L P A D V D P W R V R A A L S H D G I L N L E A P R G G R H L D T E V N E V Y I S L L P A P P D P E E E E E A A I V E P
- Accession
- Q16082
- Protein length
- Full Length
- Predicted molecular weight
- 22.8 kDa
- Amino acids
- 1 to 182
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
purified by using conventional chromatography.
General info
- Function
May regulate the kinase DMPK.
- Sequence similarities
Belongs to the small heat shock protein (HSP20) family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein HSPB2 also known as heat shock protein beta-2 functions as a small heat shock protein. It has a molecular mass of approximately 23 kDa. HSPB2 is expressed in various tissues but shows high expression in cardiac and skeletal muscles. This protein plays a role in the maintenance of cellular protein homeostasis. It binds to unfolded proteins preventing aggregation and assisting in the proper folding of client proteins under stress conditions.
- Biological function summary
HSPB2 contributes to the maintenance of muscle function. It forms complexes with other small heat shock proteins such as HSPB3 and helps in stabilizing the cytoskeletal structures during cellular stress. The protein also participates in the chaperone-assisted selective autophagy a process for the degradation of damaged proteins and organelles thereby supporting cellular integrity.
- Pathways
HSPB2 interacts significantly with the MAPK signaling pathway and is involved in stress response regulation. It associates with proteins such as HSP27 and potentially impacts pathways tied to cell survival and apoptosis. This interaction suggests a functional role in signaling processes that mediate cellular adaptation to stress often impacting downstream cellular functions such as differentiation and proliferation.
- Associated diseases and disorders
HSPB2 shows a connection to cardiomyopathies and muscular dystrophies where its expression or function might be altered. In cardiac tissue malfunction of HSPB2 leads to improper handling of stress contributing to heart conditions. It connects to proteins such as alpha-B crystallin another small heat shock protein which together protect muscle cells from damage. Understanding the role of HSPB2 in these disorders may offer insights into potential therapeutic approaches.
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1 product image
SDS-PAGE - Recombinant Human HSPB2 protein (ab126686)
15% SDS-PAGE using 3μg of ab126686.
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