JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB111632

Recombinant Human HSPB3 protein (denatured)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human HSPB3 protein (denatured) is a Human Full Length protein, in the 1 to 150 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

HSP27, HSPL27, HSPB3, Heat shock protein beta-3, HspB3, Heat shock 17 kDa protein, Heat shock protein family B member 3, Protein 3, HSP 17

1 Images
SDS-PAGE - Recombinant Human HSPB3 protein (denatured) (AB111632)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HSPB3 protein (denatured) (AB111632)

15% SDS-PAGE showing ab111632 at approximately 19.1kDa (3μg).

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q12988

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 6% Urea, 5% Glycerol (glycerin, glycerine), 0.32% Tris HCl

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK","proteinLength":"Full Length","predictedMolecularWeight":"19.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":150,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q12988","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HSPB3 also known as Heat Shock Protein Family B (Small) Member 3 is a small heat shock protein with a molecular mass of approximately 17 kDa. It plays a role in cellular stress response by interacting with partially denatured proteins to prevent their aggregation. HSPB3 expresses mainly in muscle tissues including skeletal and cardiac muscle where it supports cellular homeostasis under stress conditions.
Biological function summary

The role of HSPB3 involves ensuring protein stability and preventing harmful aggregation. It does not typically have a large complex structure as with other small heat shock proteins. Its main job is working alone to safeguard cellular functions against stress-induced damage providing a protective effect against cellular stress.

Pathways

Studies indicate that HSPB3 participates in the refolding and degradation pathways for damaged proteins. It is involved in cellular stress response mechanisms alongside other small heat shock proteins like HSPB1. These processes relate primarily to how cells manage stress and maintain protein quality control an important aspect of cellular homeostasis.

HSPB3 has links with inherited neuromuscular disorders including distal hereditary motor neuropathy. Mutations in HSPB3 may lead to malfunctioning protein responses under stress which can result in such disorders. Moreover like other small heat shock proteins it has connections to diseases involving protein misfolding and aggregation where HSPB3 and HSPB1 play roles in managing cellular responses to aberrant proteins.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Inhibitor of actin polymerization.

Sequence similarities

Belongs to the small heat shock protein (HSP20) family.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Inhibitor of actin polymerization.
See full target information HSPB3
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB48779

Recombinant Human Alpha B Crystallin protein

Western blot - Recombinant Human Alpha B Crystallin protein (AB48779)

  • 5
  • 1
Proteins & Peptides

AB124569

Recombinant Human b9HSP protein

SDS-PAGE - Recombinant Human b9HSP protein (AB124569)

  • 0
  • 0
Proteins & Peptides

AB268629

Recombinant human ErbB2 / HER2 (mutated L755W) protein (Active)

Functional Studies - Recombinant human ErbB2 / HER2 (mutated L755W) protein (Active) (AB268629)

  • 0
  • 0
Proteins & Peptides

AB268310

Recombinant human ABL1 (mutated Y253H) protein (Active)

Functional Studies - Recombinant human ABL1 (mutated Y253H) protein (Active) (AB268310)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com