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AB185404

Recombinant Human HSPB7 protein

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Recombinant Human HSPB7 protein is a Human Full Length protein, in the 1 to 170 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

CVHSP, HSPB7, Heat shock protein beta-7, HspB7, Cardiovascular heat shock protein, cvHsp

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag C-Terminus

Applications

HPLC, SDS-PAGE

applications

Biologically active

No

Accession

Q9UBY9

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.24% Tris, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as cvHSP
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Sequence info

[{"sequence":"MSHRTSSTFRAERSFHSSSSSSSSSTSSSASRALPAQDPPMEKALSMFSDDFGSFMRPHSEPLAFPARPGGAGNIKTLGDAYEFAVDVRDFSPEDIIVTTSNNHIEVRAEKLAADGTVMNTFAHKCQLPEDVDPTSVTSALREDGSLTIRARRHPHTEHVQQTFRTEIKILEHHHHHH","proteinLength":"Full Length","predictedMolecularWeight":"19 kDa","actualMolecularWeight":null,"aminoAcidEnd":170,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9UBY9","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HSPB7 also known as Heat Shock Protein Beta-7 or cvHSP is a small heat shock protein implicated in stress response mechanisms. It has a molecular mass of approximately 19 kDa. Researchers have identified its expression in cardiac and skeletal muscles as well as in adipose tissue. This protein has a protective role in preventing protein aggregation under stress conditions indicating its significance in cellular homeostasis.
Biological function summary

HSPB7 interacts with cellular components to maintain proteostasis. It participates in the formation of protein complexes binding to other small heat shock proteins to stabilize denatured proteins. This interaction serves to ensure proper protein folding and prevent aggregation within the cells. Such mechanisms highlight HSPB7’s function in maintaining muscle structure and function by assisting in protein maintenance.

Pathways

HSPB7 participates in the regulation of muscle function and stress response pathways. It connects to the MAPK signaling pathway which influences cell survival and apoptosis. Additionally HSPB7 interacts with related proteins such as HSPB2 playing a role in muscle maintenance and response to mechanical stress. These pathways highlight HSPB7’s involvement in cellular adaptation to stress stimuli.

HSPB7 has links to cardiomyopathy and muscular dystrophy. Mutations in HSPB7 correlate with an increased risk of developing familial dilated cardiomyopathy implicating it in cardiac dysfunctions. Additionally its association with proteins like HSPB1 suggests a potential role in muscle degenerative diseases. Understanding HSPB7’s role in these conditions could provide insights for therapeutic interventions aimed at mitigating muscle and heart diseases.
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Specifications

Form

Liquid

Additional notes

ab185404 is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

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General info

Sequence similarities

Belongs to the small heat shock protein (HSP20) family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

See full target information HSPB7
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Complementary Products

Primary Antibodies

AB150390

Anti-HSPB7 antibody [EPR10106(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSPB7 antibody [EPR10106(B)] (AB150390)

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