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AB107135

Recombinant Human HSPBAP1 protein

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Recombinant Human HSPBAP1 protein is a Human Full Length protein, in the 1 to 488 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

PASS1, HSPBAP1, HSPB1-associated protein 1, 27 kDa heat shock protein-associated protein 1, Protein associated with small stress protein 1

1 Images
SDS-PAGE - Recombinant Human HSPBAP1 protein (AB107135)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HSPBAP1 protein (AB107135)

15% SDS-PAGE showing ab107135 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q96EW2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAAGSEATTPVIVAAGAGGEEGEHVKPFKPEKAKEIIMSLQQPAIFCNMVFDWPARHWNAKYLSQVLHGKQIRFRMGMKSMSTVPQFETTCNYVEATLEEFLTWNCDQSSISGPFRDYDHSKFWAYADYKYFVSLFEDKTDLFQDVKWSDFGFPGRNGQESTLWIGSLGAHTPCHLDSYGCNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKAQRHAVTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHLARVEEAITRMLVCALKTAENPQNTRAWLNPTEVEETSHAVNCCYLNAAVSAFFDRCRTSEVVEIQALRTDGEHMKKEELNVCNHMEVGQTGSQNLTTGTDKPEAASPFGPDLVPVAQRSEEPPSERGGIFGSDGKDFVDKDGEHFGKLHCAKRQQIMSNSENAIEEQIASNTTTTPQTFISTDDLLDCLVNPQVTRIVAQLLIQGRSL","proteinLength":"Full Length","predictedMolecularWeight":"57.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":488,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96EW2","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein HSPBAP1 also known as HSPB1-associated protein 1 acts mechanically by interacting with small heat shock proteins particularly HSPB1. It is a polypeptide with a molecular weight of approximately 51 kDa. HSPBAP1 expresses in various tissues but its presence seems high in kidney and testis. This protein has a noted role in regulating the function and stability of its partner proteins through these interactions.
Biological function summary

HSPBAP1 contributes to the modulation of cell stress responses. It is a part of protein complexes that include small heat shock proteins. These complexes participate in maintaining cellular homeostasis by preventing aggregation and misfolding of proteins under stress conditions. HSPBAP1 involvement here reflects its importance in managing oxidative stress and maintaining normal cellular operations particularly in response to environmental changes.

Pathways

Interactions involving HSPBAP1 influence cell signaling pathways like the apoptosis pathway and stress response pathways. For instance HSPBAP1 interacts with proteins such as HSPB1 and plays a role in apoptosis regulation through modulating this key stress sensor. Furthermore it interacts with pathways that govern protein quality control within cells targeting misfolded proteins for refolding or degradation thereby impacting cellular stress resilience.

Research suggests links between HSPBAP1 and certain cancers as well as neurodegenerative diseases. Its interactions impact pathways associated with cell death and survival potentially influencing cancer progression. The link to HSPB1 a known player in stress response and cell survival may elucidate connections to cancer. Additionally misregulation of protein homeostasis associated with HSPBAP1 could contribute to conditions requiring efficient protein folding such as neurodegenerative disorders. The understanding of these interactions provides valuable insights into the protein's role in disease mechanisms.
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Specifications

Form

Liquid

Additional notes

ab107135 is purified using conventional chromatography techniques.

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General info

Function

May play a role in cellular stress response.

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Product protocols

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Target data

May play a role in cellular stress response.
See full target information HSPBAP1
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Product promise

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