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AB112304

Recombinant Human HYAL1 protein (GST tag N-Terminus)

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Recombinant Human HYAL1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 253 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

LUCA1, HYAL1, Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1

1 Images
SDS-PAGE - Recombinant Human HYAL1 protein (GST tag N-Terminus) (AB112304)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human HYAL1 protein (GST tag N-Terminus) (AB112304)

ab112304 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

Q12794

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product is useful for Antibody Production and Protein Array.
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Sequence info

[{"sequence":"MAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW","proteinLength":"Full Length","predictedMolecularWeight":"53.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":253,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q12794","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

HYAL1 also known as hyaluronidase-1 functions as an enzyme that catalyzes the degradation of hyaluronic acid into smaller oligosaccharides. It possesses a mass of approximately 57 kDa. This enzyme is expressed in various tissues including the liver spleen and kidney. HYAL1 plays an essential role in the turnover of extracellular matrix components impacting tissue remodeling and cell migration.
Biological function summary

Hyaluronidase-1 facilitates the breakdown of hyaluronic acid a major component of the extracellular matrix affecting cellular interactions and signaling pathways. HYAL1 does not operate as part of a protein complex but acts individually. Its enzymatic activity influences processes such as cell proliferation tissue repair and inflammatory response as hyaluronic acid fragments modulate these cellular behaviors.

Pathways

Hyaluronidase-1 engages in significant pathways involved in extracellular matrix organization and degradation. It interacts within the hyaluronan metabolism pathway impacting proteins like CD44 and RHAMM which are involved in cell adhesion and motility. By processing hyaluronic acid HYAL1 affects these pathways influencing cellular dynamics and homeostasis.

Abnormal HYAL1 function associates with conditions such as cancer and osteoarthritis. In cancer increased hyaluronidase-1 activity correlates with tumor progression and metastasis as it promotes cancer cell invasion through the extracellular matrix. In osteoarthritis enzymatic degradation of hyaluronic acid disrupts cartilage integrity exacerbating disease symptoms. Additionally the interaction of hyaluronidase-1 with proteins like CD44 in these conditions may further drive pathological changes.
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Specifications

Form

Solid

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General info

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

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Product protocols

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Target data

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
See full target information HYAL1
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Product promise

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