Recombinant Human HYAL1 protein is a Human Full Length protein, in the 1 to 253 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
Amino acid sequence
M A G T L Q L G R A L R P R G L W G F Y G F P D C Y N Y D F L S P N Y T G Q C P S G I R A Q N D Q L G W L W G Q S R A L Y P S I Y M P A V L E G T G K S Q M Y V Q H R V A E A F R V A V A A G D P N L P V L P Y V Q I F Y D T T N H F L P L D E L E H S L G E S A A Q G A A G V V L W V S W E N T R T K E S C Q A I K E Y M D T T L G P F I L N V T S G A L L C S Q A L C S G H G R C V R R T S H P K A L L L L N P A S F S I Q L T P G G G P L S L R G A L S L E D Q A Q M A V E F K C R C Y P G W Q A P W C E R K S M W
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
Alternative names
LUCA1, HYAL1, Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1
Recommended products
Recombinant Human HYAL1 protein is a Human Full Length protein, in the 1 to 253 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- SDS-PAGE, ELISA, WB
- Biologically active
- No
- Accession
- Q12794-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M A G T L Q L G R A L R P R G L W G F Y G F P D C Y N Y D F L S P N Y T G Q C P S G I R A Q N D Q L G W L W G Q S R A L Y P S I Y M P A V L E G T G K S Q M Y V Q H R V A E A F R V A V A A G D P N L P V L P Y V Q I F Y D T T N H F L P L D E L E H S L G E S A A Q G A A G V V L W V S W E N T R T K E S C Q A I K E Y M D T T L G P F I L N V T S G A L L C S Q A L C S G H G R C V R R T S H P K A L L L L N P A S F S I Q L T P G G G P L S L R G A L S L E D Q A Q M A V E F K C R C Y P G W Q A P W C E R K S M W
- Accession
- Q12794
- Protein length
- Full Length
- Predicted molecular weight
- 53.9 kDa
- Amino acids
- 1 to 253
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Solid
General info
- Function
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
- Sequence similarities
Belongs to the glycosyl hydrolase 56 family.
- Subcellular localisation
- Lysosome
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
This product is useful for Antibody Production and Protein Array.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
HYAL1 also known as hyaluronidase-1 functions as an enzyme that catalyzes the degradation of hyaluronic acid into smaller oligosaccharides. It possesses a mass of approximately 57 kDa. This enzyme is expressed in various tissues including the liver spleen and kidney. HYAL1 plays an essential role in the turnover of extracellular matrix components impacting tissue remodeling and cell migration.
- Biological function summary
Hyaluronidase-1 facilitates the breakdown of hyaluronic acid a major component of the extracellular matrix affecting cellular interactions and signaling pathways. HYAL1 does not operate as part of a protein complex but acts individually. Its enzymatic activity influences processes such as cell proliferation tissue repair and inflammatory response as hyaluronic acid fragments modulate these cellular behaviors.
- Pathways
Hyaluronidase-1 engages in significant pathways involved in extracellular matrix organization and degradation. It interacts within the hyaluronan metabolism pathway impacting proteins like CD44 and RHAMM which are involved in cell adhesion and motility. By processing hyaluronic acid HYAL1 affects these pathways influencing cellular dynamics and homeostasis.
- Associated diseases and disorders
Abnormal HYAL1 function associates with conditions such as cancer and osteoarthritis. In cancer increased hyaluronidase-1 activity correlates with tumor progression and metastasis as it promotes cancer cell invasion through the extracellular matrix. In osteoarthritis enzymatic degradation of hyaluronic acid disrupts cartilage integrity exacerbating disease symptoms. Additionally the interaction of hyaluronidase-1 with proteins like CD44 in these conditions may further drive pathological changes.
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1 product image
SDS-PAGE - Recombinant Human HYAL1 protein (ab112304)
ab112304 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue
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Product protocols
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