Recombinant Human HYI protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The enzyme 5-hydroxyisourate hydrolase also known as HYI plays a mechanical role in the breakdown of purines during uric acid metabolism. HYI is an important component in converting 5-hydroxyisourate to allantoin. It has a molecular mass of about 17 kDa. The expression of HYI occurs in various tissues such as the liver and kidneys. Its activity contributes to the efficient catabolism of uric acid an important process in many organisms.

Biological function summary

HYI participates in the purine degradation pathway by facilitating the conversion of intermediates helping maintain nitrogen balance in cells. The enzyme does not commonly form part of larger complexes instead acting independently to catalyze its specific reaction. In eukaryotes proper functioning of HYI prevents the accumulation of potentially harmful metabolic intermediates ensuring smooth metabolic flow.

Pathways

Purine catabolism strongly involves HYI. This enzyme ensures that 5-hydroxyisourate is efficiently processed in the uric acid degradation pathway in relation to proteins like xanthine oxidase and uricase. Through its activity HYI helps maintain efficient recycling of nitrogenous bases and supports the body's broader homeostatic balance working in tandem with other enzymes in the pathway.

Improper function or expression of HYI can associate with conditions such as gout and hyperuricemia. In these conditions uric acid accumulates leading to inflammation and pain. HYI levels can impact these disorders directly interacting with proteins involved in uric acid metabolism. Through its enzymatic role HYI stays linked to maintaining metabolic health and preventing disease progression related to purine metabolism imbalances.