Recombinant human ICAM1 protein is a Human Fragment protein, in the 28 to 480 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, FuncS.
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Key facts
- Purity
>95% SDS-PAGE
- Expression system
CHO cells
- Tags
Tag free
- Applications
SDS-PAGE, FuncS
- Biologically active
Yes
Amino acid sequence
Q T S V S P S K V I L P R G G S V L V T C S T S C D Q P K L L G I E T P L P K K E L L L P G N N R K V Y E L S N V Q E D S Q P M C Y S N C P D G Q S T A K T F L T V Y W T P E R V E L A P L P S W Q P V G K N L T L R C Q V E G G A P R A N L T V V L L R G E K E L K R E P A V G E P A E V T T T V L V R R D H H G A N F S C R T E L D L R P Q G L E L F E N T S A P Y Q L Q T F V L P A T P P Q L V S P R V L E V D T Q G T V V C S L D G L F P V S E A Q V H L A L G D Q R L N P T V T Y G N D S F S A K A S V S V T A E D E G T Q R L T C A V I L G N Q S Q E T L Q T V T I Y S F P A P N V I L T K P E V S E G T E V T V K C E A H P R A K V T L N G V P A Q P L G P R A Q L L L K A T P E D N G R S F S C S A T L E V A G Q L I H K N Q T R E L R V L Y G P R L D E R D C P G N W T W P E N S Q Q T P M C Q A W G N P L P E L K C L K D G T F P L P I G E S V T V T R D L E G T Y L C R A R S T Q G E V T R K V T V N V L S P R Y E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Alternative names
Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, ICAM1
Recommended products
Recombinant human ICAM1 protein is a Human Fragment protein, in the 28 to 480 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, FuncS.
Alternative names
Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, ICAM1
Key facts
- Purity
>95% SDS-PAGE
- Expression system
CHO cells
- Tags
Tag free
- Applications
SDS-PAGE, FuncS
- Biologically active
Yes
- Biological activity
ab82125 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25μg/ml ICAM1 concentration
- Accession
- P05362-1
- Animal free
No
- Species
Human
- Concentration
Sequence info
Amino acid sequence
Q T S V S P S K V I L P R G G S V L V T C S T S C D Q P K L L G I E T P L P K K E L L L P G N N R K V Y E L S N V Q E D S Q P M C Y S N C P D G Q S T A K T F L T V Y W T P E R V E L A P L P S W Q P V G K N L T L R C Q V E G G A P R A N L T V V L L R G E K E L K R E P A V G E P A E V T T T V L V R R D H H G A N F S C R T E L D L R P Q G L E L F E N T S A P Y Q L Q T F V L P A T P P Q L V S P R V L E V D T Q G T V V C S L D G L F P V S E A Q V H L A L G D Q R L N P T V T Y G N D S F S A K A S V S V T A E D E G T Q R L T C A V I L G N Q S Q E T L Q T V T I Y S F P A P N V I L T K P E V S E G T E V T V K C E A H P R A K V T L N G V P A Q P L G P R A Q L L L K A T P E D N G R S F S C S A T L E V A G Q L I H K N Q T R E L R V L Y G P R L D E R D C P G N W T W P E N S Q Q T P M C Q A W G N P L P E L K C L K D G T F P L P I G E S V T V T R D L E G T Y L C R A R S T Q G E V T R K V T V N V L S P R Y E
- Accession
- Protein length
Fragment
- Amino acids
28 to 480
- Nature
Recombinant
Specifications
- Form
Lyophilized
- Additional notes
Purity is greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
General info
- Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
- Sequence similarities
Belongs to the immunoglobulin superfamily. ICAM family.
- Post-translational modifications
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Stable for 12 months at -20°C
This product is an active protein and may elicit a biological response in vivo, handle with caution.
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Terms & Conditions.
1 product image
Sandwich ELISA - Recombinant human ICAM1 protein (ab82125)
Standard curve for ICAM1 (Analyte: ab82125); dilution range 1pg/ml to 1μg/ml using Capture Antibody Anti-ICAM1 antibody [MEM-111] ab2213 at 5μg/ml and Detector Antibody Biotin Anti-ICAM1 antibody ab7815 at 0.5μg/ml.
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