Recombinant Human ICAM2 protein (Fc Chimera His Tag) is a Human Fragment protein, in the 1 to 223 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M S S F G Y R T L T V A L F T L I C C P G S D E K V F E V H V R P K K L A V E P K G S L E V N C S T T C N Q P E V G G L E T S L D K I L L D E Q A Q W K H Y L V S N I S H D T V L Q C H F T C S G K Q E S M N S N V S V Y Q P P R Q V I L T L Q P T L V A V G K S F T I E C R V P T V E P L D S L T L F L F R G N E T L H Y E T F G K A A P A P Q E A T A T F N S T A D R E D G H R N F S C L A V L D L M S R G G N I F H K H S A P K M L E I Y E P V S D S Q
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Alternative names
CD102, Intercellular adhesion molecule 2, ICAM-2, ICAM2
Recommended products
Recombinant Human ICAM2 protein (Fc Chimera His Tag) is a Human Fragment protein, in the 1 to 223 aa range, expressed in HEK 293, with >97% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >97% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- Fc tag C-Terminus His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P13598-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M S S F G Y R T L T V A L F T L I C C P G S D E K V F E V H V R P K K L A V E P K G S L E V N C S T T C N Q P E V G G L E T S L D K I L L D E Q A Q W K H Y L V S N I S H D T V L Q C H F T C S G K Q E S M N S N V S V Y Q P P R Q V I L T L Q P T L V A V G K S F T I E C R V P T V E P L D S L T L F L F R G N E T L H Y E T F G K A A P A P Q E A T A T F N S T A D R E D G H R N F S C L A V L D L M S R G G N I F H K H S A P K M L E I Y E P V S D S Q
- Accession
- P13598
- Protein length
- Fragment
- Predicted molecular weight
- 50.3 kDa
- Amino acids
- 1 to 223
- Nature
- Recombinant
- Tags
- Fc tag C-Terminus, His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
- Sequence similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
ICAM2 also known as IC2 or ICAM-2 is a cell surface glycoprotein with a molecular mass of approximately 55-65 kDa. It plays an important role in immune response. The protein belongs to the immunoglobulin superfamily and interacts specifically with integrin molecules. ICAM2 is expressed widely across many tissues including endothelial cells platelets and leukocytes. Its primary function involves facilitating stable adhesion between leukocytes and endothelial cells which is essential for leukocyte transmigration.
- Biological function summary
ICAM2 helps in immune function by serving as an adhesion molecule. It does not form part of a larger protein complex but instead it acts independently to mediate interactions between cells. It contributes to leukocyte rolling and firm adhesion stages necessary for leukocyte extravasation. This function is important in immune surveillance and response to infection allowing immune cells to quickly migrate to sites of inflammation.
- Pathways
ICAM2 operates in the leukocyte adhesion and transendothelial migration pathways. It interacts closely with integrins especially LFA-1 present on leukocytes and this interaction supports cell movement during immune responses. It also participates in signaling pathways that activate immune cells further aiding in the regulation of immune cell activity. These interactions make ICAM2 a critical component in immunological communication and signal transduction pathways.
- Associated diseases and disorders
ICAM2 is associated with conditions involving immune dysfunction and inflammation. For instance abnormal expression of ICAM2 has been linked to inflammatory diseases such as atherosclerosis. Additionally it plays a role in the pathology of multiple sclerosis where it might influence the migration of immune cells across the blood-brain barrier. Its relationship with integrins highlights its potential relevance in therapeutic strategies to modulate immune responses in these diseases.
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SDS-PAGE - Recombinant Human ICAM2 protein (Fc Chimera His Tag) (ab276250)
SDS-PAGE analysis of ab276250
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