Recombinant Human ICAM4 protein is a Human Fragment protein, in the 43 to 210 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
>90% SDS-PAGE
Escherichia coli
His-DHFR tag N-Terminus
SDS-PAGE
No
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
Intercellular adhesion molecule 4, ICAM-4, Landsteiner-Wiener blood group glycoprotein, LW blood group protein, LW, ICAM4
Recombinant Human ICAM4 protein is a Human Fragment protein, in the 43 to 210 aa range, expressed in Escherichia coli, with >90% purity and suitable for SDS-PAGE.
Intercellular adhesion molecule 4, ICAM-4, Landsteiner-Wiener blood group glycoprotein, LW blood group protein, LW, ICAM4
>90% SDS-PAGE
Escherichia coli
His-DHFR tag N-Terminus
SDS-PAGE
No
No
Human
Reconstitute with water to desired concentration.
Constituents: 0.58% Sodium chloride, 0.32% Tris HCl
Fragment
18.4 kDa
43 to 210
Recombinant
His-DHFR tag N-Terminus
Lyophilized
Purified via His tag
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
Belongs to the immunoglobulin superfamily. ICAM family.
N- and O-glycosylated.
Blue Ice
-20°C
This supplementary information is collated from multiple sources and compiled automatically.
ICAM4 also known as CD242 functions as an intercellular adhesion molecule with a mass of approximately 42 kDa. It is mainly expressed on erythrocytes and plays a role in cell-cell adhesion. ICAM4 binds selectively with integrins especially those located on the surface of leukocytes and endothelial cells. This protein facilitates critical interactions that allow cells to communicate and engage with their environment efficiently.
The protein enables erythrocytes to adhere to vascular endothelium by interacting with other molecules such as integrins. It acts independently and not as part of a larger protein complex. ICAM4 serves as an inherent mediator in maintaining the stability and flexibility of red blood cells during circulation ensuring these cells can navigate through capillaries without significant issues.
The process of erythrocyte adhesion involves ICAM4's interaction in the immune response system. Particularly it takes part in pathways connected to cell adhesion and signaling that influence leukocyte-endothelial interaction. Proteins like LFA-1 and Mac-1 specific integrins associate with ICAM4 playing essential parts in immunological functions that determine cell adhesion dynamics.
ICAM4 holds an association with sickle cell disease a genetic disorder affecting hemoglobin in erythrocytes. Abnormal adhesion properties linked to ICAM4 exacerbate vascular occlusion contributing to the pathology of the condition. ICAM4 may also relate to malaria as the altered binding interactions impact the sequestration of parasitized erythrocytes. In these disease settings interactions with proteins like integrins contribute significantly to their pathological manifestations.
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