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AB276709

Recombinant Human ICAM5 protein (His tag)

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(1 Publication)

Recombinant Human ICAM5 protein (His tag) is a Human Fragment protein, in the 1 to 834 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

TLCN, TLN, ICAM5, Intercellular adhesion molecule 5, ICAM-5, Telencephalin

1 Images
SDS-PAGE - Recombinant Human ICAM5 protein (His tag) (AB276709)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ICAM5 protein (His tag) (AB276709)

SDS-PAGE analysis of ab276709

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9UMF0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS, 5% Trehalose, 5% Mannitol, 0.01% Tween 80

storage-buffer

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Complementary Products

Primary Antibodies

AB28304

Anti-ADAM23 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody (AB28304)

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  • 0
Primary Antibodies

AB302899

Anti-ICAM5 antibody [EPR25850-86]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry - Anti-ICAM5 antibody [EPR25850-86] (AB302899)

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Primary Antibodies

AB197924

Anti-CATSPER3 antibody

Western blot - Anti-CATSPER3 antibody (AB197924)

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  • 0
Primary Antibodies

AB188329

Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal

RabMAb|Recombinant

Western blot - Anti-TXNDC11/EFP1 antibody [EPR14314] - C-terminal (AB188329)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP","proteinLength":"Fragment","predictedMolecularWeight":"87.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":834,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9UMF0","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ICAM5 also known as Telencephalin is an intercellular adhesion molecule with a molecular mass of approximately 130 kDa. This protein is mainly expressed in the brain specifically in neurons of the telencephalon region. ICAM5 belongs to the immunoglobulin superfamily and plays a role in cell-cell adhesion. It does not demonstrate tight adherence like other ICAMs which suggests its specific function might differ from other ICAM family members.
Biological function summary

ICAM5 participates in neuron-neuron adhesion processes. It plays a significant role in the development and maintenance of synaptic structures in the nervous system. ICAM5 does not form a complex with other proteins in its functioning. It contributes to the organization and stabilization of dendritic spines which are important for synaptic plasticity and neural communication. This involvement highlights the importance of ICAM5 in neural development and synaptic function.

Pathways

ICAM5 integrates into signaling pathways related to neuronal development and synaptic plasticity. It is a part of the adhesion and cell recognition processes in neural systems. Through its involvement ICAM5 associates with pathways like the glutamatergic synapse pathway. Additionally ICAM5 shows a connection with proteins involved in membrane transport and neuronal signaling such as NMDARs (N-methyl-D-aspartate receptors) emphasizing its role in synaptic modulation.

ICAM5 relates to conditions affecting the nervous system such as schizophrenia and Alzheimer's disease. Studies indicate alterations in ICAM5 expression levels in patients with these diseases suggesting a potential impact on synaptic integrity and function. In Alzheimer's disease ICAM5 interacts with pathways involving beta-amyloid peptide accumulation indicating a possible connection with oxidative stress and neurodegenerative processes. In schizophrenia disruptions in ICAM5 associations with neural adhesion molecules could affect synaptic signaling and stability contributing to cognitive deficits.
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Specifications

Form

Lyophilized

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General info

Function

Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL : ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed : 8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed : 10893271).

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.

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Product protocols

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Target data

Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL : ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed : 8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed : 10893271).
See full target information ICAM5
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Scientific data 11:868 PubMed39127790

2024

An image-based screen for secreted proteins involved in breast cancer G0 cell cycle arrest.

Applications

Unspecified application

Species

Unspecified reactive species

William A Weston,Jordan A Holt,Anna J Wiecek,James Pilling,Lovisa Holmberg Schiavone,David M Smith,Maria Secrier,Alexis R Barr
View all publications
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Product promise

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