Recombinant Human ICEBERG protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The ICEBERG protein also known by its alternate name of CARD18 mechanically acts as a regulator in the inflammatory process. It possesses a molecular mass of approximately 23 kDa. Expression of ICEBERG is notable in tissues like the spleen thymus and also in peripheral blood leukocytes. This protein contains a caspase recruitment domain (CARD) and interacts with other proteins through this domain to perform its regulatory functions.

Biological function summary

ICEBERG serves to inhibit the activation of caspase-1 by binding to its precursor pro-caspase-1 therefore preventing its conversion to an active form. This inhibition is critical because ICEBERG forms an important part of larger protein complexes that control inflammation by modulating the production of cytokines such as IL-1β. Through its action ICEBERG helps maintain balance within immune responses stopping overactivation that can harm tissues.

Pathways

The ICEBERG protein holds importance in the inflammatory and immune response pathways. It interacts closely with proteins such as procaspase-1 and NOD-like receptors (NLRs) which play important roles in mediating the body's response to infections and injuries. By inhibiting the activity in the inflammasome pathway ICEBERG directly affects how immune cells like macrophages react to pathogens.

ICEBERG is critically linked to conditions such as rheumatoid arthritis and Crohn's disease. These diseases involve chronic inflammation where dysregulation of cytokine production can lead to significant tissue damage. The protein often associates with other inflammatory regulators like IL-1β distinguishing targets for potentially developing therapies that aim to modulate immune responses and treat such inflammatory disorders.