Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active)
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Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active) is a Human Fragment protein, in the 19 to 256 aa range, expressed in HEK 293 cells, with >95%, <0.005 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC, Mass Spec.
View Alternative Names
CD275, B7H2, B7RP1, ICOSL, KIAA0653, ICOSLG, ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, B7-H2, B7RP-1
- Biological Activity
Supplier Data
Biological Activity - Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active) (AB307632)
Loaded Human ICOS Ligand, Human Fc Tag on Protein A Biosensor can bind Human ICOS, His Tag with an affinity constant of 117 nM as determined in BLI assay (GatorBio Prime).
- Mass Spec
Supplier Data
Mass Spectrometry - Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active) (AB307632)
Mass determination by ESI-TOF. Predicted MW is 52358.50 (+/-10 Da by ESI-TOF). Observed MW is 52237.13 Da.
- HPLC
Supplier Data
HPLC - Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active) (AB307632)
HPLC analysis of ab307632
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human ICOS Ligand/ICOSL Protein (Fc Chimera) (Active) (AB307632)
SDS-PAGE analysis of ab307632
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ICOSL contributes to the modulation of immune responses. By forming a complex with the active ICOS protein ICOSL is involved in the co-stimulation of T cells. This process is important for the development of T-cell-dependent immune responses and helps in promoting the survival and differentiation of T cells. Together the ICOS ligand and ICOS protein create a dynamic interaction that balances immune activation and tolerance which is essential for maintaining immune homeostasis.
Pathways
The ICOS-ICOSL interaction plays an important role in the T-cell receptor (TCR) signaling pathway. This pathway is fundamental for the activation of T cells and subsequent immune response. ICOSL also connects to the PI3K/Akt pathway where it impacts cell survival and proliferation. ICOS and the PI3K/Akt pathway work together to influence various aspects of immune regulation and adaptive immunity.
Specifications
Form
Lyophilized
Additional notes
SDS-PAGE >= 95%
General info
Function
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed : 11007762, PubMed : 11023515, PubMed : 30498080). Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity). In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP) (PubMed : 30498080).
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Target data
Complementary Products
Product promise
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