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AB113598

Recombinant Human IDI1 protein

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Recombinant Human IDI1 protein is a Human Full Length protein, in the 1 to 228 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Isopentenyl-diphosphate Delta-isomerase 1, Isopentenyl pyrophosphate isomerase 1, IPP isomerase 1, IPPI1, IDI1

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SDS-PAGE - Recombinant Human IDI1 protein (AB113598)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IDI1 protein (AB113598)

SDS-PAGE analysis of ab113598.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q13907

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMMPEINTNHLDKQQVQLLAEMCILIDENDNKIGAETKKNCHLNENIEKGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELEESDALGVRRAAQRRLKAELGIPLEEVPPEEINYLTRIHYKAQSDGIWGEHEIDYILLVRKNVTLNPDPNEIKSYCYVSKEELKELLKKAASGEIKITPWFKIIAATFLFKWWDNLNHLNQFVDHEKIYRM","proteinLength":"Full Length","predictedMolecularWeight":"28.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":228,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13907","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IDI1 also known as Isopentenyl-diphosphate delta isomerase 1 plays an important role in isoprenoid biosynthesis. The protein facilitates the conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) an essential step in the biosynthetic pathway. This enzyme has a molecular mass of approximately 44 kDa. You can find IDI1 expressions mainly in the liver though it is also noted in other tissues including the heart and kidneys.
Biological function summary

IDI1 contributes to the formation of isoprenoids which are essential for numerous cellular functions like cholesterol synthesis and protein prenylation. It principally operates as a monomer and does not typically associate with a larger protein complex during its activity. The enzyme's role in positioning alongside other essential enzymes makes it significant for the transcriptional regulation of certain metabolic processes.

Pathways

IDI1 participates extensively in the mevalonate pathway a fundamental route for cholesterol biosynthesis. It functions under the regulation of proteins like HMG-CoA reductase a rate-limiting enzyme in this pathway. The enzyme also connects to the isoprenoid biosynthesis pathway where it interacts with proteins involved in the synthesis of farnesyl pyrophosphate a precursor in the generation of various biomolecules.

IDI1 links with metabolic conditions such as hypercholesterolemia and Smith-Lemli-Opitz syndrome both affecting cholesterol levels. The interaction with proteins such as DHCR7 involved in the conversion of 7-dehydrocholesterol to cholesterol highlights its implication in these disorders. Dysfunction in IDI1 activity might lead to the disruption of regular metabolic balance further impacting cellular health.
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Specifications

Form

Liquid

Additional notes

ab113598 was purified using conventional chromatography.

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General info

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Sequence similarities

Belongs to the IPP isomerase type 1 family.

Subcellular localisation

Peroxisome

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Product protocols

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Target data

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
See full target information IDI1
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