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AB105602

Recombinant Human IDI2 protein

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Recombinant Human IDI2 protein is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Isopentenyl-diphosphate delta-isomerase 2, Isopentenyl pyrophosphate isomerase 2, IPP isomerase 2, IPPI2, IDI2

1 Images
SDS-PAGE - Recombinant Human IDI2 protein (AB105602)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human IDI2 protein (AB105602)

15% SDS-PAGE showing ab105602 (3μg) at approximately 28.9 kDa.

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q9BXS1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00174% PMSF

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFNTKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPGEQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELWELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV","proteinLength":"Full Length","predictedMolecularWeight":"28.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":227,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BXS1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IDI2 or isopentenyl-diphosphate delta isomerase 2 is an enzyme with an important role in the mevalonate pathway. This protein facilitates the conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) a vital step in the production of isoprenoids. The enzyme has a molecular mass of approximately 30 kDa. Expression of IDI2 occurs mainly in skeletal muscle and to a lesser extent in the heart.
Biological function summary

The enzymatic activity of IDI2 contributes to the synthesis of isoprenoid compounds that are essential for cellular processes. IDI2 functions individually not as a part of a larger protein complex. Isoprenoids produced through the function of IDI2 serve as vital components for cholesterol synthesis and protein prenylation within cells impacting cellular signaling and structural integrity.

Pathways

The IDI2 enzyme plays a role in the mevalonate pathway which is important for the biosynthesis of cholesterol and isoprenoids. This pathway along with IDI2 interacts functionally with other enzymes like HMG-CoA reductase which also participates in cholesterol synthesis. Understanding the IDI2 enzyme within these pathways highlights its relationship with other metabolic processes critical for cellular function.

Mutations or dysregulation of IDI2 can relate to metabolic disorders and muscular issues. Specifically aberrant functioning of the mevalonate pathway where IDI2 is significant often contributes to diseases such as mevalonate kinase deficiency. Interaction between IDI2 and proteins in this pathway such as HMG-CoA reductase can lead to impacts on cholesterol homeostasis linked to cardiovascular conditions.
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Specifications

Form

Liquid

Additional notes

ab105602 is purified using conventional chromatography techniques.

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General info

Function

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).

Sequence similarities

Belongs to the IPP isomerase type 1 family.

Subcellular localisation

Peroxisome

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Product protocols

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Target data

Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
See full target information Isopentenyl-diphosphate delta-isomerase 2
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