JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB161220

Recombinant Human IFI44L protein (GST tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human IFI44L protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 413 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

C1orf29, GS3686, IFI44L, Interferon-induced protein 44-like

1 Images
SDS-PAGE - Recombinant Human IFI44L protein (GST tag N-Terminus) (AB161220)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human IFI44L protein (GST tag N-Terminus) (AB161220)

ab161220 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q53G44

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB161390

Recombinant Human UBP43/USP18 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human UBP43/USP18 protein (GST tag N-Terminus) (AB161390)

  • 0
  • 0
Proteins & Peptides

AB159886

Recombinant Human ZP2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human ZP2 protein (GST tag N-Terminus) (AB159886)

  • 0
  • 0
Proteins & Peptides

AB162402

Recombinant Human Zinc finger protein 691 (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Zinc finger protein 691 (GST tag N-Terminus) (AB162402)

  • 0
  • 0
Proteins & Peptides

AB161146

Recombinant Human BS69 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human BS69 protein (GST tag N-Terminus) (AB161146)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MVERCSRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQPCI","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":413,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q53G44","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The interferon-induced protein 44-like (IFI44L) is a protein encoded by the IFI44L gene. It is also known as IFI44L protein or sometimes simply IFI44L. This protein has a molecular mass of around 49 kDa. IFI44L is broadly expressed in many tissues with higher expression in blood and spleen. Mechanically IFI44L contributes to the antiviral response by being induced by type I and type II interferons. Its exact mechanism of action involves modulation in response to viral infection although full details of how it works are still not completely understood.
Biological function summary

IFI44L plays an active role in the body's defense against viral infections. It participates as part of the broader immune response. While not being recognized as a classic element of a large protein complex it interacts with cellular machinery responsible for immune regulation and interferon signaling. This protein contributes towards the establishment of an antiviral state in affected cells through mechanisms which are yet to be completely defined. Its inducible nature makes it an important part of how cells respond to foreign viral components.

Pathways

This target connects to the interferon signaling pathway which is important for antiviral defenses. IFI44L plays a significant role in the broader cytokine signaling pathways particularly those related to type I interferon responses. It interacts with proteins such as MX1 and IFIT1 which are important elements of the interfacing network that responds to viral challenges in the cell. These relationships help in sustaining a robust antiviral state within the host.

IFI44L is linked to conditions like systemic lupus erythematosus (SLE) and viral infections such as hepatitis C. This can be due to its regulatory role in immune responses and interferon signaling. In SLE where interferon activity is often dysregulated IFI44L expression can be elevated. It also connects with proteins like IFI27 and ISG15 which are similarly upregulated in response to viral infections and are implicated in the pathogenesis of these diseases. Understanding IFI44L's function and interactions further aids in exploring therapeutic approaches for these conditions.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed : 34722780). During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed : 34722780). Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed : 32611756). Exhibits a low antiviral activity against hepatitis C virus (PubMed : 21478870). Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed : 31434731).

Sequence similarities

Belongs to the IFI44 family.

style
left-column

Product protocols

style
left-column

Target data

Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed : 34722780). During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed : 34722780). Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed : 32611756). Exhibits a low antiviral activity against hepatitis C virus (PubMed : 21478870). Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed : 31434731).
See full target information IFI44L
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com