Recombinant Human IFITM2 protein (6x His + GST)
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Recombinant Human IFITM2 protein (6x His + GST) is a Human Full Length protein, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB, Mass Spec.
View Alternative Names
Interferon-induced transmembrane protein 2, Dispanin subfamily A member 2c, Interferon-inducible protein 1-8D, DSPA2c, IFITM2
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human IFITM2 protein (AB92922)
ab92922 analysed on 10% SDS-PAGE and stained with Coomassie Blue (1) or detected by western blot analysis with an antibody to the proprietary tag (2).
Complementary Products
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The role of IFITM2 extends beyond mechanical blocking as it participates in the immune response by inhibiting the fusion of viral membranes with endosomal membranes. IFITM2 operates together with IFITM1 and IFITM3 forming a complex that boosts its antiviral capacity. The protein contributes to the defense mechanism against a broad range of viral pathogens including influenza and dengue viruses.
Pathways
Research shows that IFITM2 is involved in the interferon signaling pathway which regulates immune response to pathogens. In this pathway IFITM proteins are part of the type I and type II interferon responses enhancing cellular resistance to viral infection. The protein collaborates with others such as STAT1 in maintaining cellular defenses against pathogens.
Specifications
Form
Solid
General info
Function
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed : 26354436, PubMed : 33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed : 26354436, PubMed : 33239446, PubMed : 33270927, PubMed : 33563656). Can inhibit : influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed : 33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed : 26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed : 26354436).
Sequence similarities
Belongs to the CD225/Dispanin family.
Post-translational modifications
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity.. Phosphorylation at Tyr-19 is required for endosomal and lysosomal location.
Subcellular localisation
Lysosome membrane
Target data
Product promise
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