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AB124549

Recombinant Human IFNA14 protein

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Recombinant Human IFNA14 protein is a Human Full Length protein, in the 24 to 189 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Interferon alpha-14, IFN-alpha-14, Interferon alpha-H, Interferon lambda-2-H, LeIF H, IFNA14

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SDS-PAGE - Recombinant Human IFNA14 protein (AB124549)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human IFNA14 protein (AB124549)

15% SDS-PAGE (3 μg loaded)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

P01570

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMCNLSQTHSLNNRRTLMLMAQMRRISPFSCLKDRHDFEFPQEEFDGNQFQKAQAISVLHEMMQQTFNLFSTKNSSAAWDETLLEKFYIELFQQMNDLEACVIQEVGVEETPLMNEDSILAVKKYFQRITLYLMEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD","proteinLength":"Full Length","predictedMolecularWeight":"22.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P01570","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

IFNA14 also known as Interferon Alpha-14 is a low molecular weight protein weighing approximately 19.3 kDa. It belongs to the type I interferon family and functions as a cytokine. IFNA14 is primarily expressed in leukocytes where it exerts its effects on various immune responses. This protein contributes to the antiviral boundaries of cells by binding to specific cell-surface receptors.
Biological function summary

IFNA14 plays an essential role in the immune system response to viral infections. It interacts with the type I interferon receptor complex to activate transcription of interferon-stimulated genes which help to mediate antiviral effects. IFNA14 signals through the JAK-STAT pathway ultimately leading to an increased expression of MHC class I antigens and enhanced immune recognition. Its activity aids in the coordination of the immune system's efforts to combat viral pathogens.

Pathways

IFNA14 is integral to the interferon signaling pathway and plays a part in the innate immune response pathway. These pathways involve a cascade of proteins including JAK1 and STAT2 which mediate its signal transduction. The activation of these pathways leads to transcriptional changes necessary for an effective antiviral state and modulation of the immune response.

IFNA14 has connections with viral infections like Hepatitis C and systemic lupus erythematosus (SLE). Its dysregulation or overexpression can lead to an inappropriate immune response contributing to the pathogenesis of these conditions. The relationship between IFNA14 and other interferon-induced proteins such as IRF7 highlights its significance in disease progression and points to potential therapeutic targets.
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Specifications

Form

Liquid

Additional notes

Purified by using conventional chromatography.

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General info

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.

Sequence similarities

Belongs to the alpha/beta interferon family.

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Product protocols

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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA14
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Complementary Products

Primary Antibodies

AB235515

Anti-IFNA14 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IFNA14 antibody (AB235515)

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