Recombinant Human IFNA4 protein is a Human Full Length protein, in the 24 to 189 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
C D L P Q T H S L G N R R A L I L L A Q M G R I S H F S C L K D R H D F G F P E E E F D G H Q F Q K T Q A I S V L H E M I Q Q T F N L F S T E D S S A A W E Q S L L E K F S T E L Y Q Q L N D L E A C V I Q E V G V E E T P L M N E D S I L A V R K Y F Q R I T L Y L T E K K Y S P C A W E V V R A E I M R S L S F S T N L Q K R L R R K D V D H H H H H H
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application HPLC | Reactivity Reacts | Dilution info - | Notes - |
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Interferon alpha-4, IFN-alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, IFNA4
Recombinant Human IFNA4 protein is a Human Full Length protein, in the 24 to 189 aa range, expressed in HEK 293, with >95% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, HPLC.
pH: 7.4
Constituents: 99% Phosphate Buffer, 0.87% Sodium chloride
Purity greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Belongs to the alpha/beta interferon family.
The IFNA4 gene encodes a member of the alpha interferon family commonly known as Interferon alpha-4 (IFN-α4). This protein plays an important role in the immune response acting as a signaling molecule that helps regulate the activity of the immune system. IFN-α4 consists of approximately 20 kilodaltons in mass. It is expressed in various tissues but is most abundant in blood cells and at sites of infection or inflammation.
Interferon alpha-4 engages in antiviral defense mechanisms by binding to specific receptors on the surface of cells triggering a cascade of cellular responses to represent an antiviral state. This state restricts viral replication within host cells. IFN-α4 forms part of a diverse family of cytokines known as type I interferons. These cytokines all share the common mechanism of activating immune responses.
The involvement of interferon alpha-4 in the Jak-STAT pathway is significant for transducing signals that lead to the expression of interferon-stimulated genes (ISGs). It closely interacts with other proteins like STAT1 and STAT2 which play important roles in this signaling cascade. By triggering these pathways IFN-α4 and related proteins contribute to the host's defense against infections.
Abnormalities in IFN-α4 expression or function can relate to autoimmune diseases such as Systemic Lupus Erythematosus (SLE) where excessive interferon activity can damage tissues. Chronic Hepatitis C infection is another condition linked to this protein where altered IFN-α responsiveness complicates viral clearance. IFN-α4's interactions with other cytokines such as IFN-β may also influence the disease states and progression.
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