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AB276252

Recombinant human IFNA4 protein (Fc Chimera)

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Recombinant human IFNA4 protein (Fc Chimera) is a Human Fragment protein, in the 23 to 189 aa range, expressed in HEK 293 cells, with >97%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Interferon alpha-4, IFN-alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, IFNA4

2 Images
Functional Studies - Recombinant human IFNA4 protein (Fc Chimera) (AB276252)
  • FuncS

Supplier Data

Functional Studies - Recombinant human IFNA4 protein (Fc Chimera) (AB276252)

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).
The EC50 for this effect is 0.2-1 ng/mL.

SDS-PAGE - Recombinant human IFNA4 protein (Fc Chimera) (AB276252)
  • SDS-PAGE

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SDS-PAGE - Recombinant human IFNA4 protein (Fc Chimera) (AB276252)

SDS-PAGE analysis of ab276252

Key facts

Purity

>97% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

Fc tag N-Terminus

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).
The EC50 for this effect is 0.2-1 ng/mL.

Accession

P05014

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"GCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD","proteinLength":"Fragment","predictedMolecularWeight":"46 kDa","actualMolecularWeight":null,"aminoAcidEnd":189,"aminoAcidStart":23,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P05014","tags":[{"tag":"Fc","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
True
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The IFNA4 gene encodes a member of the alpha interferon family commonly known as Interferon alpha-4 (IFN-α4). This protein plays an important role in the immune response acting as a signaling molecule that helps regulate the activity of the immune system. IFN-α4 consists of approximately 20 kilodaltons in mass. It is expressed in various tissues but is most abundant in blood cells and at sites of infection or inflammation.
Biological function summary

Interferon alpha-4 engages in antiviral defense mechanisms by binding to specific receptors on the surface of cells triggering a cascade of cellular responses to represent an antiviral state. This state restricts viral replication within host cells. IFN-α4 forms part of a diverse family of cytokines known as type I interferons. These cytokines all share the common mechanism of activating immune responses.

Pathways

The involvement of interferon alpha-4 in the Jak-STAT pathway is significant for transducing signals that lead to the expression of interferon-stimulated genes (ISGs). It closely interacts with other proteins like STAT1 and STAT2 which play important roles in this signaling cascade. By triggering these pathways IFN-α4 and related proteins contribute to the host's defense against infections.

Abnormalities in IFN-α4 expression or function can relate to autoimmune diseases such as Systemic Lupus Erythematosus (SLE) where excessive interferon activity can damage tissues. Chronic Hepatitis C infection is another condition linked to this protein where altered IFN-α responsiveness complicates viral clearance. IFN-α4's interactions with other cytokines such as IFN-β may also influence the disease states and progression.
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Specifications

Form

Lyophilized

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General info

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.

Sequence similarities

Belongs to the alpha/beta interferon family.

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Product protocols

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Target data

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
See full target information IFNA4
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