Recombinant human IFNA5 protein (Fc Chimera)
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Recombinant human IFNA5 protein (Fc Chimera) is a Human Full Length protein, in the 22 to 189 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.
View Alternative Names
Interferon alpha-5, IFN-alpha-5, Interferon alpha-61, Interferon alpha-G, LeIF G, IFNA5
- FuncS
Supplier Data
Functional Studies - Recombinant human IFNA5 protein (Fc Chimera) (AB276255)
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus (VSV).
The EC50 for this effect is 0.16-0.8 ng/mL.
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant human IFNA5 protein (Fc Chimera) (AB276255)
SDS-PAGE analysis of ab276255
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
This interferon functions in immune modulation and antiviral defense mechanisms. IFNA5 does not operate alone; it is involved with other signaling molecules to exert its effects contributing to a multi-protein complex known as the interferon-stimulated gene factor 3 (ISGF3). This complex activates the transcription of interferon-stimulated genes which are key players in the body's defense against viruses and other pathogens.
Pathways
Interferon alpha-5 contributes significantly to the Jak-STAT signaling pathway pivotal for transmitting information from chemical signals outside the cell to the cell nucleus. In this pathway it frequently interacts with proteins like Jak1 and STAT1 both essential in propagating antiviral and cellular defense signals. IFNA5 also engages in the innate immune response cooperating with other proteins to maintain and enhance defense against infectious agents.
Specifications
Form
Lyophilized
General info
Function
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes : a protein kinase and an oligoadenylate synthetase.
Sequence similarities
Belongs to the alpha/beta interferon family.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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