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AB173053

Recombinant Human IGF2BP2/IMP-2 protein

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(1 Publication)

Recombinant Human IGF2BP2/IMP-2 protein is a Human Fragment protein, in the 1 to 220 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

View Alternative Names

IMP2, VICKZ2, IGF2BP2, Insulin-like growth factor 2 mRNA-binding protein 2, IGF2 mRNA-binding protein 2, IMP-2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2

1 Images
SDS-PAGE - Recombinant Human IGF2BP2/IMP-2 protein (AB173053)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human IGF2BP2/IMP-2 protein (AB173053)

SDS-PAGE analysis of Recombinant Human IGF2BP2 (ab173053).

Lane 1 + 2 : Recombinant Human IGF2BP2.
Lane 3 : Molecular weight markers.

Key facts

Purity

>95% SDS-PAGE

Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

His tag C-Terminus T7 tag N-Terminus

Applications

SDS-PAGE, HPLC

applications

Biologically active

No

Accession

Q9Y6M1

Animal free

No

Carrier free

No

Species

Human

Reconstitution

Reconstitute in water

Storage buffer

pH: 7.4 Constituents: Phosphate Buffer, 0.877% Sodium chloride

storage-buffer

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Complementary Products

Primary Antibodies

AB124930

Anti-IGF2BP2/IMP-2 antibody [EPR6741(B)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IGF2BP2/IMP-2 antibody [EPR6741(B)] (AB124930)

  • 4
  • 1
Primary Antibodies

AB290736

Anti-IGF2BP1/IMP1 antibody [EPR26408-18]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant

Multiplex immunohistochemistry - Anti-IGF2BP1/IMP1 antibody [EPR26408-18] (AB290736)

  • 0
  • 0
Primary Antibodies

AB114997

Anti-IRF2BP2 antibody

Immunoprecipitation - Anti-IRF2BP2 antibody (AB114997)

  • 0
  • 0
Primary Antibodies

AB177477

Anti-IMP3 antibody [EPR12021]

20ul selling size|RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-IMP3 antibody [EPR12021] (AB177477)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Previously labelled as IGF2BP2.
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Sequence info

[{"linker":null,"sequence":"MASMTGGQQMGRGSEFMMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRKIQIRNIPPHLQWEVLDGLLAQYGTVENVEQVNTDTETAVVNVTYATREEAKIAMEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITLEHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"27.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":220,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9Y6M1","tags":[{"tag":"His","terminus":"C-Terminus"},{"tag":"T7","terminus":"N-Terminus"}]}]
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Properties and storage information

Form
Lyophilized
Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
False
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General info

Function

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed : 29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed : 9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed : 29476152).

Sequence similarities

Belongs to the RRM IMP/VICKZ family.

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Product protocols

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Target data

RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (PubMed : 29476152). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs (PubMed : 9891060). Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (PubMed : 29476152).
See full target information IGF2BP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:680642 PubMed34386421

2021

Long Non-Coding RNA CCAT2 Promotes the Development of Esophageal Squamous Cell Carcinoma by Inhibiting miR-200b to Upregulate the IGF2BP2/TK1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaodan Wu,Yihui Fan,Yupeng Liu,Biao Shen,Haimin Lu,Haitao Ma
View all publications
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