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Recombinant human IL-15 protein (Active) is a Human Full Length protein, expressed in HEK 293, with >=95% purity, < 0.005 EU/µg endotoxin level and suitable for sELISA, SDS-PAGE, FuncS, MS, HPLC, Cell Culture.

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Purity

>=95% SDS-PAGE

Endotoxin level

< 0.005 EU/µg

Expression system

HEK 293 cells

Tags

Tag free

Applications

sELISA, SDS-PAGE, FuncS, MS, HPLC, Cell Culture

Biologically active

Yes

Reactivity data

Application
sELISA
Reactivity
Reacts
Dilution info
-
Notes

-

Application
SDS-PAGE
Reactivity
Reacts
Dilution info
-
Notes

-

Application
FuncS
Reactivity
Reacts
Dilution info
-
Notes

-

Application
MS
Reactivity
Reacts
Dilution info
-
Notes

-

Application
HPLC
Reactivity
Reacts
Dilution info
-
Notes

-

Application
Cell Culture
Reactivity
Reacts
Dilution info
-
Notes

-

Images

Target data

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Recombinant human IL-15 protein (Active) is a Human Full Length protein, expressed in HEK 293, with >=95% purity, < 0.005 EU/µg endotoxin level and suitable for sELISA, SDS-PAGE, FuncS, MS, HPLC, Cell Culture.

Key facts

Purity

>=95% SDS-PAGE

Endotoxin level

< 0.005 EU/µg

Expression system

HEK 293 cells

Applications

sELISA, SDS-PAGE, FuncS, MS, HPLC, Cell Culture

Biological activity

Fully biologically active determined by the dose dependent proliferation of KHYG-1 cells.

ED50 is ≤1.28 ng/mL, corresponding to a specific activity of 7.8 x 105 units/mg.

Predicted molecular weight

12.8 kDa

Accession
P40933-1
Protein length

Full Length

Animal free

Yes

Nature

Recombinant

Species

Human

Reconstitution

Reconstitute with Phosphate Buffered saline.Reconstituted protein stable at -80C for 12 months or 4C for 1 week. Lyophilized contents may appear as either a translucent film or a white powder. This variance does not affect the quality of the product.

Concentration
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Storage buffer

pH: 6 - 8
Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.248% Potassium phosphate monobasic

Specifications

Form

Lyophilized

Additional notes

>= 95 % HPLC.

General info

Function

Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).

Sequence similarities

Belongs to the IL-15/IL-21 family.

Subcellular localisation

Nucleus

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

Ambient

This product is an active protein and may elicit a biological response in vivo, handle with caution.

Notes

This protein is filter sterilised prior to aliquoting and lyophilisation. All aliquoting and lyophilisation steps are performed in a sterile environment

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

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