JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB256039

Recombinant human IL-16 protein (Active)

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant human IL-16 protein (Active) is a Human Fragment protein, in the 1203 to 1332 aa range, expressed in Escherichia coli, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, FuncS.

View Alternative Names

Pro-interleukin-16, IL16

1 Images
SDS-PAGE - Recombinant human IL-16 protein (Active) (AB256039)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant human IL-16 protein (Active) (AB256039)

SDS-PAGE analysis of ab256039 (1μg) under non-reducing (Lane 1) and reducing (Lane 2) conditions. ab256039 has a predicted weight of 13.4kDa.

4-20% Tris-Glycine gel. Coomassie Blue staining.

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

Escherichia coli

Tags

Tag free

Applications

FuncS, SDS-PAGE

applications

Biologically active

Yes

Biological activity

Primary human T cell chemotaxis.

Accession

Q14005

Animal free

No

Carrier free

Yes

Species

Human

Reconstitution

Reconstitute at 0.1 mg/mL in water

Storage buffer

Constituents: 0.16% Sodium phosphate

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS","proteinLength":"Fragment","predictedMolecularWeight":"13.4 kDa","actualMolecularWeight":null,"aminoAcidEnd":1332,"aminoAcidStart":1203,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q14005","tags":[]}]
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
True
style
left-column
style
left-column

Specifications

Form

Lyophilized

style
left-column

General info

Function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.. Isoform 1. May act as a scaffolding protein that anchors ion channels in the membrane.. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Post-translational modifications

Isoform 3. Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.

Subcellular localisation

Nucleus

style
left-column

Product protocols

style
left-column

Target data

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.. Isoform 1. May act as a scaffolding protein that anchors ion channels in the membrane.. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
See full target information IL16
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Emerging microbes & infections 13:2322663 PubMed38380651

2024

hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth.

Applications

Unspecified application

Species

Unspecified reactive species

Haibo Su,Shufeng Weng,Liulin Luo,Qin Sun,Taiyue Lin,Huixia Ma,Yumo He,Jing Wu,Honghai Wang,Wenhong Zhang,Ying Xu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB7817

Anti-alpha smooth muscle Actin antibody [1A4]

KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [1A4] (AB7817)

  • 5
  • 105
Primary Antibodies

AB251467

Anti-IL-16 antibody [EPR19988] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL-16 antibody [EPR19988] - BSA and Azide free (AB251467)

  • 0
  • 0
Proteins & Peptides

AB259410

Recombinant human TNF alpha protein (Active)

Premium Bioactive

Flow Cytometry - Recombinant human TNF alpha protein (Active) (AB259410)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com